Metastatic urothelial carcinoma

Metastatic urothelial carcinoma

The following considers the results of Chemotherapy on Metastatic urothelial carcinoma.

"Patients with refractory advanced or metastatic urothelial carcinoma derive only minor benefit from chemotherapy".[1]

Various studies have shown combination chemotherapy to have an effect. Treatment with chemotherapy and "infusion cisplatin and high-dose 5-fluorouracil/leucovorin (P-HDFL)" results in a median survival of 38 months.[2]

Donald Kaufman worked on a study using a combination of gemcitabine and cisplatin, which resulted in a median survival of 14.3 months.[3]

Generally speaking, treatment with chemotherapy will not with any amount of certainty, extend one's life.

References

  1. ^ Kim J, Millikan RE, Smith TL, Tu SM, Pagliaro LC, Logothetis CJ (2003). "Treating refractory advanced or metastatic urothelial carcinoma with interleukin-2: a phase II study". Urol. Oncol. 21 (1): 21–6. PMID 12684123. http://linkinghub.elsevier.com/retrieve/pii/S1078143902002077. 
  2. ^ Lin CC, Hsu CH, Huang CY, et al. (March 2007). "Prognostic factors for metastatic urothelial carcinoma treated with cisplatin and 5-fluorouracil-based regimens". Urology 69 (3): 479–84. doi:10.1016/j.urology.2006.12.010. PMID 17382149. http://linkinghub.elsevier.com/retrieve/pii/S0090-4295(06)02634-3. 
  3. ^ Kaufman D, Raghavan D, Carducci M, et al. (May 2000). "Phase II trial of gemcitabine plus cisplatin in patients with metastatic urothelial cancer". J. Clin. Oncol. 18 (9): 1921–7. PMID 10784633. http://www.jco.org/cgi/pmidlookup?view=long&pmid=10784633. 
v · d · eTumors: urogenital neoplasia: urinary organs (C64–C68/D30, 188–189/223)
Abdominal
Kidney
Glandular and epithelial neoplasm: Renal cell carcinoma · Renal oncocytoma
by location: Renal medullary carcinoma · Juxtaglomerular cell tumor · Renal medullary fibroma
Ureter
Pelvic
Retroperitoneum

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