Urotensin-II receptor

Urotensin-II receptor

The urotensin-II receptor (also referred to as the hypocretin receptor) is a G-protein coupled receptor which binds the peptide hormone urotensin-II.cite journal | author = Douglas SA, Dhanak D, Johns DG | title = From 'gills to pills': urotensin-II as a regulator of mammalian cardiorenal function | journal = Trends Pharmacol. Sci. | volume = 25 | issue = 2 | pages = 76–85 | year = 2004 | pmid = 15102493 | doi = 10.1016/j.tips.2003.12.005 | issn = ]

References

Further reading

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citations =
*cite journal | author=Marchese A, Heiber M, Nguyen T, "et al." |title=Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors. |journal=Genomics |volume=29 |issue= 2 |pages= 335–44 |year= 1996 |pmid= 8666380 |doi=
*cite journal | author=Coulouarn Y, Lihrmann I, Jegou S, "et al." |title=Cloning of the cDNA encoding the urotensin II precursor in frog and human reveals intense expression of the urotensin II gene in motoneurons of the spinal cord. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 26 |pages= 15803–8 |year= 1999 |pmid= 9861051 |doi=
*cite journal | author=Ames RS, Sarau HM, Chambers JK, "et al." |title=Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14. |journal=Nature |volume=401 |issue= 6750 |pages= 282–6 |year= 1999 |pmid= 10499587 |doi= 10.1038/45809
*cite journal | author=Liu Q, Pong SS, Zeng Z, "et al." |title=Identification of urotensin II as the endogenous ligand for the orphan G-protein-coupled receptor GPR14. |journal=Biochem. Biophys. Res. Commun. |volume=266 |issue= 1 |pages= 174–8 |year= 2000 |pmid= 10581185 |doi= 10.1006/bbrc.1999.1796
*cite journal | author=Protopopov A, Kashuba V, Podowski R, "et al." |title=Assignment of the GPR14 gene coding for the G-protein-coupled receptor 14 to human chromosome 17q25.3 by fluorescent in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=88 |issue= 3-4 |pages= 312–3 |year= 2000 |pmid= 10828617 |doi=
*cite journal | author=Maguire JJ, Kuc RE, Davenport AP |title=Orphan-receptor ligand human urotensin II: receptor localization in human tissues and comparison of vasoconstrictor responses with endothelin-1. |journal=Br. J. Pharmacol. |volume=131 |issue= 3 |pages= 441–6 |year= 2001 |pmid= 11015293 |doi= 10.1038/sj.bjp.0703601
*cite journal | author=Sugo T, Murakami Y, Shimomura Y, "et al." |title=Identification of urotensin II-related peptide as the urotensin II-immunoreactive molecule in the rat brain. |journal=Biochem. Biophys. Res. Commun. |volume=310 |issue= 3 |pages= 860–8 |year= 2003 |pmid= 14550283 |doi=
*cite journal | author=Birker-Robaczewska M, Boukhadra C, Studer R, "et al." |title=The expression of urotensin II receptor (U2R) is up-regulated by interferon-gamma. |journal=J. Recept. Signal Transduct. Res. |volume=23 |issue= 4 |pages= 289–305 |year= 2004 |pmid= 14753294 |doi=
*cite journal | author=Bousette N, Patel L, Douglas SA, "et al." |title=Increased expression of urotensin II and its cognate receptor GPR14 in atherosclerotic lesions of the human aorta. |journal=Atherosclerosis |volume=176 |issue= 1 |pages= 117–23 |year= 2004 |pmid= 15306183 |doi= 10.1016/j.atherosclerosis.2004.03.023
*cite journal | author=Suzuki S, Wenyi Z, Hirai M, "et al." |title=Genetic variations at urotensin II and urotensin II receptor genes and risk of type 2 diabetes mellitus in Japanese. |journal=Peptides |volume=25 |issue= 10 |pages= 1803–8 |year= 2005 |pmid= 15476949 |doi= 10.1016/j.peptides.2004.03.030
*cite journal | author=Qi JS, Minor LK, Smith C, "et al." |title=Characterization of functional urotensin II receptors in human skeletal muscle myoblasts: comparison with angiotensin II receptors. |journal=Peptides |volume=26 |issue= 4 |pages= 683–90 |year= 2005 |pmid= 15752584 |doi= 10.1016/j.peptides.2004.11.018
*cite journal | author=Lehner U, Velić A, Schroter R, "et al." |title=Ligands and signaling of the G-protein-coupled receptor GPR14, expressed in human kidney cells. |journal=Cell. Physiol. Biochem. |volume=20 |issue= 1-4 |pages= 181–92 |year= 2007 |pmid= 17595527 |doi= 10.1159/000104165
*cite journal | author=Segain JP, Rolli-Derkinderen M, Gervois N, "et al." |title=Urotensin II is a new chemotactic factor for UT receptor-expressing monocytes. |journal=J. Immunol. |volume=179 |issue= 2 |pages= 901–9 |year= 2007 |pmid= 17617581 |doi=

External links

* [http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2444 IUPHAR GPCR Database - Urotensin receptor]
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