Bromisoval

drugbox
IUPAC_name = 2-bromo-"N"-carbamoyl-3-methylbutanamide

---

CAS_number = 496-67-3
ChemSpiderID = 2353
ATC_prefix = N05
ATC_suffix = CM03
PubChem = 2447
DrugBank =
C=6|H=11|Br=1|N=2|O=2
molecular_weight = 223.068 g/mol
bioavailability =
protein_bound =
metabolism =
elimination_half-life =
excretion =
pregnancy_AU =
pregnancy_US =
pregnancy_category=
legal_AU =
legal_CA =
legal_UK =
legal_US =
legal_status =
routes_of_administration = Oral

Bromisoval (INN; commonly known as bromvalerylurea) is a hypnotic and sedative. It is marketed over the counter in Asia under various trade names, usually in combination with non-steroidal anti-inflammatory drugs.

Chronic use of bromisoval has been associated with bromine poisoning. [cite journal |author=Hashida H, Honda T, Morimoto H, Aibara Y |title= [A case of chronic bromvalerylurea intoxication due to habitual use of commercially available nonsteroidal anti-inflammatory drugs presenting an indefinite hyperchloremia] |language=Japanese |journal=Nippon Ronen Igakkai Zasshi (Japanese Journal of Geriatrics) |volume=38 |issue=5 |pages=700–3 |year=2001 |pmid=11605223 |doi=] [cite journal |author=Kawakami T, Takiyama Y, Yanaka I, "et al" |title=Chronic bromvalerylurea intoxication: dystonic posture and cerebellar ataxia due to nonsteroidal anti-inflammatory drug abuse |journal=Intern Med |volume=37 |issue=9 |pages=788–91 |year=1998 |pmid=9804091 |doi=] [cite journal |author=Wang YT, Yang SY, Wu VC, Wu KD, Fang CC |title=Pseudohyperchloraemia due to bromvalerylurea abuse |journal=Nephrol Dial Transplant |volume=20 |issue=8 |pages=1767–8 |year=2005 |pmid=15972320 |doi=10.1093/ndt/gfh945 [http://ndt.oxfordjournals.org/cgi/content/full/20/8/1767-aFree full text] ]

References