Prolintane

drugbox
IUPAC_name = 1-(1-phenylpentan-2-yl)pyrrolidine


CAS_number = 493-92-5
ATC_prefix = N06
ATC_suffix = BX14
PubChem = 14592
DrugBank =
C=15|H=23|N=1
molecular_weight = 217.35 g/mol
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Prolintane (Promotil, Katovit) is a psychostimulant/nootropic. [Hollister LE, Gillespie HK. A new stimulant, prolintane hydrochloride, compared with dextroamphetamine in fatigued volunteers. "Journal of Clinical Pharmacology and the Journal of New Drugs". 1970 Mar-Apr;10(2):103-9. PMID 4392006]

Prolintane is a stimulant closely related in structure to other drugs such as pyrovalerone and has a similar mechanism of action, by inhibiting the reuptake of dopamine and other monoamine neurotransmitters. Prolintane is a mild stimulant with a good safety profile and relatively low incidence of cardiovascular problems or other side effects such as anorexia and insomnia, although these side effects may still occur at higher doses. [Nicholson AN, Stone BM, Jones MM. Wakefullness and reduced rapid eye movement sleep: studies with prolintane and pemoline. "British Journal of Clinical Pharmacology". 1980 Nov;10(5):465-72. PMID 7437258] However the good safety profile of this drug at low doses makes it suitable for use in elderly people to increase motivation and counteract the effects of senile dementia and age-related cognitive decline. [Kuitunen T, Kärkkäinen S, Ylitalo P. Comparison of the acute physical and mental effects of ephedrine, fenfluramine, phentermine and prolintane. "Methods and Findings in Experimental and Clinical Pharmacology". 1984 May;6(5):265-70. PMID 6471970] It is mainly used in European countries.

Prolintane may also be abused as a recreational stimulant and use for this purpose has reportedly been increasing in recent years. [Payá B, Guisado JA, Vaz FJ, Crespo-Facorro B. Visual hallucinations induced by the combination of prolintane and diphenhydramine. "Pharmacopsychiatry". 2002 Jan;35(1):24-5. PMID 11819155] [Gaulier JM, Canal M, Pradeille JL, Marquet P, Lachâtre G. New drugs at "rave parties": ketamine and prolintane. (French). "Acta Clinica Belgica. Supplementum". 2002;(1):41-6. PMID 11974443] [Kyle PB, Daley WP. Domestic abuse of the European rave drug prolintane. "Journal of Analytical Toxicology". 2007 Sep;31(7):415-8. PMID 17725890]

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