12-O-Tetradecanoylphorbol-13-acetate

Chembox new
Name = Tetradecanoylphorbol acetate
ImageFile = Tetradecanoylphorbol_acetate.png ImageName = TPA
IUPACName =12-O-tetradecanoylphorbol-13-acetate
OtherNames = TPA, PMA, Phorbol myristate acetate,
Tetradecanoylphorbol acetate.
Section1 = Chembox Identifiers
CASNo = 16561-29-8
-
PubChem
PubChem|10475874
Section2 = Chembox Properties
Formula = C36H56O8
MolarMass = 616.83 g/mol

12-O-Tetradecanoylphorbol-13-acetate (TPA), also commonly known as phorbol 12-myristate 13-acetate (PMA), is diester of phorbol and a potent tumor promoter often employed in biomedical research to activate the signal transduction enzyme protein kinase C (PKC). The effects of TPA on PKC result from its similarity to one of the natural activators of classic PKC isoforms, diacylglycerol.TPA is also being studied as a drug in the treatment of hematologic cancer. TPA is not to be confused with tPA; the former is a small molecule drug, whereas the latter is an enzyme.TPA was first found in the croton plant, a shrub found in Southeast Asia, exposure to which provokes a poison ivy-like rash. It is currently undergoing phase 1 clinical trials.

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