Cardiotrophin 1

Cardiotrophin 1

protein
Name=cardiotrophin 1
caption=


width=
HGNCid=2499
Symbol=CTF1
AltSymbols=
EntrezGene=1489
OMIM=600435
RefSeq=NM_001330
UniProt=Q16619
PDB=
ECnumber=
Chromosome=16
Arm=p
Band=11.2
LocusSupplementaryData=-16p11.1

Cardiotrophin-1 (CT-1) is a cytokine. It is a cardiac hypertrophic factor of 21.5 kDa and a protein member of the IL-6 cytokine family. CT-1 is associated with the pathophysiology of heart diseases, including hypertension, myocardial infarction, valvular heart disease, and congestive heart failure. The protein exerts its cellular effects by interacting with the glycoprotein 130 (gp130)/leukemia inhibitory factor receptor beta (LIFR) heterodimer. In addition, CT-1 activates phosphatidylinositol 3-kinase (PI-3 kinase) in cardiac myocytes and enhances transcription factor NF-κB DNA -binding activities. CT-1 is highly expressed in the heart, skeletal muscle, prostate and ovary and to lower levels in lung, kidney, pancreas, thymus, testis and small intestine. [ [http://www.abcam.com/index.html?datasheet=9838] ]

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