Proteomic Code

The Proteomic Code is a set of rules by which information in genetic material is transferred into the physicochemical properties of amino acids and determines how individual amino acids interact with each other during folding and in specific protein-protein interactions. The Proteomic Code is part of the redundant Genetic Code. The 25 years old history of this concept is reviewed from the first suggestion in 1981 [ Biro J. Comparative analysis of specificity in protein-protein interactions. Part II.: The complementary coding of some proteins as the possible source of specificity in protein-protein interactions. Med Hypotheses. 1981 Aug;7(8):981-93. ] through the discovery of a Common Periodic Table of Codons and Nucleic acids in 2003 [ Biro JC, Benyo B, Sansom C, Szlavecz A, Fordos G, Micsik T, Benyo Z. A common periodic table of codons and amino acids. Biochem Biophys Res Commun. 2003 Jun 27;306(2):408-15. ] and the recent conceptualization of partial complementary coding of interacting amino acids [ Biro JC. Protein folding information in nucleic acids which is not present in the genetic code. Annals of the New York Academy of Sciences 1091 (1), 399 – 411.(2006). ] as well as the theory of the nucleic acid assisted protein folding. [ Biro JC Nucleic Acid Chaperons: A theory of an RNA-assisted Protein Folding. Theor Biol Med Model. 1;2:35, 2005 ]

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