Small nucleolar RNA TBR7

Small nucleolar RNA TBR7 is a non-coding RNA (ncRNA) molecule identified in "Trypanosoma brucei" which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifiying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

snoRNA TBR7 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs [cite journal | last = Galardi | first = S | coauthors = Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I | year = 2002 | title = Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro | journal = Mol Cell Biol | volume = 22 | pages = 6663–6668 | pmid = 12215523 | doi = 10.1128/MCB.22.19.6663-6668.2002] .

TBR7 was one of seventeen snoRNAs identified in Trypanosoma brucei by immunoprecipiation with anti-fibrillarin antibodies cite journal | author = Dunbar DA, Wormsley S, Lowe TM, Baserga SJ | title = Fibrillarin-associated box C/D small nucleolar RNAs in Trypanosoma brucei. Sequence conservation and implications for 2'-O-ribose methylation of rRNA | journal = J. Biol. Chem. | volume = 275 | issue = 19 | pages = 14767–76 | year = 2000 | pmid = 10747997 | doi = | issn = ] . It is predicted to guide the 2'O ribosose methylation of 18s ribosomal RNA (rRNA).

References

External links

*