Enterovirus cis-acting replication element

Enterovirus cis-acting replication element

Enterovirus cis-acting replication element is a small RNA hairpin in the coding region of protein 2C as the site in PV1(M) RNA that is used as the primary template for the "in vitro" uridylylation [1-2] . The first step in the replication of the plus-stranded poliovirus RNA is the synthesis of a complementary minus strand. This process is initiated by the covalent attachment of Uridine monophosphate (UMP) to the terminal protein VPg, yielding VPgpU and VPgpUpU.

References

* [1] cite journal | last = Paul | first = AV | coauthors = Rieder E, Kim DW, van Boom JH, Wimmer E | year = 2000 | title = Identification of an RNA hairpin in poliovirus RNA that serves as the primary template in the in vitro uridylylation of VPg | journal = J Virol | volume = 74 | pages = 10359–10370 | pmid = 11044080 | doi = 10.1128/JVI.74.22.10359-10370.2000
* [2] cite journal | last = Goodfellow | first = I | coauthors = Chaudhry Y, Richardson A, Meredith J, Almond JW, Barclay W, Evans DJ | year = 2000 | title = Identification of a cis-acting replication element within the poliovirus coding region | journal = J Virol | volume = 74 | pages = 4590–4600 | pmid = 10775595 | doi = 10.1128/JVI.74.10.4590-4600.2000

External links

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