Nav1.9

sodium channel, voltage-gated, type XI, alpha subunit
Available structures PDB 1byy
Identifiers
Symbols	SCN11A; NaN; SCN12A
External IDs	OMIM: 604385 MGI: 1345149 HomoloGene: 8041 IUPHAR: Nav1.9 GeneCards: SCN11A Gene
Gene Ontology Molecular function • voltage-gated ion channel activity • voltage-gated potassium channel activity • ion channel activity • voltage-gated calcium channel activity • voltage-gated sodium channel activity • sodium ion binding Cellular component • membrane • voltage-gated sodium channel complex • integral to membrane • voltage-gated calcium channel complex • voltage-gated potassium channel complex Biological process • potassium ion transport • response to drug • calcium ion transport • sodium ion transport • ion transport Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	11280	24046
Ensembl	ENSG00000168356	ENSMUSG00000034115
UniProt	Q9UI33	Q810E1
RefSeq (mRNA)	NM_014139	NM_011887
RefSeq (protein)	NP_054858	NP_036017
Location (UCSC)	Chr 3: 38.86 – 38.97 Mb	Chr 9: 119.66 – 119.73 Mb
PubMed search	[1]	[2]

Sodium channel, voltage-gated, type XI, alpha subunit also known as SCN11A or Na_v1.9 is a voltage-gated sodium ion channel protein which in humans is encoded by the SCN11A gene.^[1][2]

References

1. ^ Dib-Hajj S, Black JA, Cummins TR, Waxman SG (2002). "NaN/Nav1.9: a sodium channel with unique properties". Trends Neurosci. 25 (5): 253–9. doi:10.1016/S0166-2236(02)02150-1. PMID 11972962. 
2. ^ Dib-Hajj SD, Tyrrell L, Waxman SG (2002). "Structure of the sodium channel gene SCN11A: evidence for intron-to-exon conversion model and implications for gene evolution". Mol. Neurobiol. 26 (2–3): 235–50. doi:10.1385/MN:26:2-3:235. PMID 12428758. 

Further reading

• Delmas P, Coste B (2003). "Na+ channel Nav1.9: in search of a gating mechanism". Trends Neurosci. 26 (2): 55–7. doi:10.1016/S0166-2236(02)00030-9. PMID 12536125. 
• Blum R, Kafitz KW, Konnerth A (2002). "Neurotrophin-evoked depolarization requires the sodium channel Na(V)1.9". Nature 419 (6908): 687–93. doi:10.1038/nature01085. PMID 12384689. 
• Raymond CK, Castle J, Garrett-Engele P et al. (2004). "Expression of alternatively spliced sodium channel alpha-subunit genes. Unique splicing patterns are observed in dorsal root ganglia". J. Biol. Chem. 279 (44): 46234–41. doi:10.1074/jbc.M406387200. PMID 15302875. 
• Dib-Hajj SD, Tyrrell L, Escayg A et al. (1999). "Coding sequence, genomic organization, and conserved chromosomal localization of the mouse gene Scn11a encoding the sodium channel NaN". Genomics 59 (3): 309–18. doi:10.1006/geno.1999.5890. PMID 10444332. 
• Dib-Hajj SD, Tyrrell L, Cummins TR et al. (1999). "Two tetrodotoxin-resistant sodium channels in human dorsal root ganglion neurons". FEBS Lett. 462 (1–2): 117–20. doi:10.1016/S0014-5793(99)01519-7. PMID 10580103. 
• Jeong SY, Goto J, Hashida H et al. (2000). "Identification of a novel human voltage-gated sodium channel alpha subunit gene, SCN12A". Biochem. Biophys. Res. Commun. 267 (1): 262–70. doi:10.1006/bbrc.1999.1916. PMID 10623608. 
• Goldin AL, Barchi RL, Caldwell JH et al. (2000). "Nomenclature of voltage-gated sodium channels". Neuron 28 (2): 365–8. doi:10.1016/S0896-6273(00)00116-1. PMID 11144347. 
• Catterall WA, Goldin AL, Waxman SG (2005). "International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels". Pharmacol. Rev. 57 (4): 397–409. doi:10.1124/pr.57.4.4. PMID 16382098. 

External links

• MeSH SCN11A+protein,+human

Na+: Sodium channel
Constitutively active Epithelial sodium channel (α, β, γ, δ) Proton gated Amiloride-sensitive cation channel (1, 2, 3, 4) Voltage-gated Navα (1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 7A) · Navβ (1, 2, 3, 4)

K+: Potassium channel
Voltage-gated Kvα1-6 (1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8) · (2.1, 2.2) · (3.1, 3.2, 3.3, 3.4) · (4.1, 4.2, 4.3) · (5.1) · (6.1, 6.2, 6.3, 6.4) Kvα7-12 (7.1, 7.2, 7.3, 7.4, 7.5) · (8.1, 8.2) · (9.1, 9.2, 9.3) · (10.1, 10.2) · (11.1/hERG, 11.2, 11.3) · (12.1, 12.2, 12.3) Kvβ (1, 2, 3) · KCNIP (1, 2, 3, 4) · minK/ISK · minK/ISK-like · MiRP (1, 2, 3) · Shaker gene Calcium-activated BK channel (α1, β1, β2, β3, β4) · SK channel (SK1, SK2, SK3, SK4) · KCa (1.1, 2.1, 2.2, 2.3, 3.1, 4.1, 4.2, 5.1) Inward-rectifier KATP · Kir (1.1, 2.1, 2.2, 2.3, 2.4, 2.6) · GIRK/Kir (3.1, 3.2, 3.3, 3.4) · Kir (4.1, 4.2, 5.1, 6.1, 6.2, 7.1) Tandem pore domain K2P (1, 2, 3, 4, 5, 6, 7, 9, 10, 12, 13, 15, 16, 17, 18)

Other
Cl-: Chloride channel ANO1 · Bestrophin (1, 2) · CFTR · CLCA (1, 2, 3, 4) · CLCN (1, 2, 3, 4, 5, 6, 7, KA, KB) · CLIC (1, 2, 3, 4, 5, 6, L1) · CLNS (1A, 1B) H+: Voltage-gated HVCN1 M+: TRP cation channel TRPA (1) · TRPC (1, 2, 3, 4, 4AP, 5, 6, 7) · TRPM (1, 2, 3, 4, 5, 6, 7, 8) · TRPML (1, 2, 3) · TRPP (1, 2) · TRPV (1, 2, 3, 4, 5, 6) Cyclic nucleotide-gated (FC) α (1, 2, 3, 4) · β (1, 2, 3) · HCN (1, 2, 3, 4) Porin Aquaporin (1, 2, 3, 4, 5, 7, 8, 9) · Voltage-dependent anion channel (1, 2, 3) · General bacterial porin family Gap junction Connexin: A (GJA1, GJA3, GJA4, GJA5, GJA8, GJA9, GJA10) · B (GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7) · C (GJC1, GJC2, GJC3) · D (GJD2, GJD3, GJD4)) Innexin General Ligand-gated ion channel · Voltage-gated ion channel · Stretch-activated ion channel

see also disorders
B memb: cead, trns (1A, 1C, 1F, 2A, 3A1, 3A2-3, 3D), othr