- Electrophilic addition
In
organic chemistry , an electrophilic addition reaction is anaddition reaction where, in achemical compound , api bond is removed by the creation of two newcovalent bond s. In Electrophilic addition reactions, common substrates have a carbon-carbondouble bond ortriple bond .Y-Z + C=C → Y-C-C-Z
The driving force for this reaction is the formation of an
electrophile Y+ that forms acovalent bond with an electron-rich unsaturated C=C bond. The positive charge on Y is transferred to the carbon-carbon bond.Step (1) Y+ + C=C → Y-C-C+-
In step 2 of an Electrophilic addition, the positively charged intermediate combines with (Z) that is electron-rich to form the second covalent bond.
Step (2) Y-C-C+- + Z → Y-C-C-Z
Step 2 is also found in a
SN1 reaction . The exact nature of the electrophile and the nature of the positively charged intermediate is not always clear and depends on reactants and reaction conditions.In all asymmetric addition reactions to Carbon
Regioselectivity is important and often determined byMarkovnikov's rule .Organoborane compounds give anti-Markovnikov additions. Electrophilic attack to anaromatic system results inelectrophilic aromatic substitution rather than an addition reaction.Typical electrophilic additions
Typical electrophilic additions to alkenes with reagents are:
*dihalo addition reaction s: X2
*Hydrohalogenation s:HX
*Hydration reaction s: H2O
*Hydrogenation s H2
*Oxymercuration reaction s: mercuric acetate, water
*Hydroboration-oxidation reaction s : diborane
* thePrins reaction : formaldehyde, water
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