- Clofedanol
-
Chlophedianol 
Systematic (IUPAC) name 1-(2-chlorophenyl)-3-dimethylamino-
1-phenyl-propan-1-olClinical data AHFS/Drugs.com Micromedex Detailed Consumer Information Pregnancy cat. ? Legal status ? Routes Oral Identifiers CAS number 791-35-5 
ATC code R05DB10 PubChem CID 2795 DrugBank DB04837 ChemSpider 2693 UNII 42C50P12AP KEGG D07721 ChEMBL CHEMBL1201313 
Chemical data Formula C17H20ClNO Mol. mass 289.8 g/mol SMILES eMolecules & PubChem - InChI=1S/C17H20ClNO/c1-19(2)13-12-17(20,14-8-4-3-5-9-14)15-10-6-7-11-16(15)18/h3-11,20H,12-13H2,1-2H3
Key:WRCHFMBCVFFYEQ-UHFFFAOYSA-N
(what is this?) (verify)Clofedanol (INN) or chlophedianol (BAN) is a centrally-acting cough suppressant used in the treatment of dry cough. Clofedanol has local anesthetic and antihistamine properties, and may have anticholinergic effects at high doses.[1] It is marketed in Canada under the trade name Ulone, but is not available currently in the United States. In August 2009, Centrix Pharmaceutical announced the launch of a cough syrup containing a mixture of clophedianol and pseudoephedrine, marketed under the brand name Clofera. It has a release to market date in the beginning of the fourth quarter 2009[2]. Chlophedianol was approved for OTC status in 1987 by the FDA OTC monograph process[3] and its safety and efficacy data are limited.
References
- ^ (French) "Clofedanol". BIAM. 1998-07-24. http://www.biam2.org/www/Sub4074.html. Retrieved 2007-04-15.
- ^ "Centrix Pharmaceutical Announces Clofera(TM), a Unique Antitussive and Nasal Decongestant for the Temporary Relief of Cough and Nasal Congestion". Cenrx.com. http://www.cenrx.com/news.php. Retrieved 2009-09-27.
- ^ "Department of Health and Human Services. Food and Drug Administration. 21 CFR Parts 310, 341, and 369. Docket No. 76N-052T. Cold, cough, allergy, bronchodilator, and antiasthmatic drug products for over-the0counter human use; final monograph for OTC antitussive drug products. Federal Register 1987;52(155):30042-57". FDA.gov. 1987-08-12. http://www.fda.gov/downloads/Drugs/DevelopmentApprovalProcess/DevelopmentResources/Over-the-CounterOTCDrugs/StatusofOTCRulemakings/ucm114742.pdf.
Cough and cold preparations (R05) Expectorants Mucolytics Acetylcysteine • Ambroxol • Bromhexine • Carbocisteine • Domiodol • Dornase alfa • Eprazinone • Erdosteine • Letosteine • Mesna • Neltenexine • Sobrerol • Stepronin • TioproninCough suppressants Acetyldihydrocodeine • Benzylmorphine • Codeine • Dextromethorphan • Diacetylmorphine • Dihydrocodeine • Dimemorfan • Droxypropine • Ethylmorphine • Hydrocodone • Hydromorphone • Isoaminile • Laudanum • Levomethadone • Levopropoxyphene • Methadone • Nicocodeine • Nicodicodeine • Normethadone • Noscapine • Pholcodine • Thebacon • Tipepidine • ZipeprolOtherBenzonatate • Benproperine • Bibenzonium bromide • Butamirate • Clobutinol • Clofedanol • Cloperastine • Diphenhydramine • Dibunate • Dimethoxanate • Dropropizine • Fedrilate • Glaucine • Levodropropizine • Meprotixol • Morclofone • Nepinalone • Oxolamine • Oxeladin • Pentoxyverine • Pipazetate • Prenoxdiazine • Piperidione
This drug article relating to the respiratory system is a stub. You can help Wikipedia by expanding it. - InChI=1S/C17H20ClNO/c1-19(2)13-12-17(20,14-8-4-3-5-9-14)15-10-6-7-11-16(15)18/h3-11,20H,12-13H2,1-2H3
