Fibrocyte

Fibrocyte

Fibrocyte is a very old term used to identify inactive mesenchymal cells, that is cells showing minimal cytoplasm,limited amounts of rough endoplasmic reticulum and lack of biochemical evidence of synthesis of proteins. The term "fibrocyte" contrasts with the term "fibroblast." Fibroblasts are connective tissue cells characterized by synthesis of proteins of the fibrous matrix, particularly the collagens. When tissue is injured, the predominant mesenchymal cells, the fibroblast, have been believed to be derived from the fibrocyte or possibly from smooth muscle cells lining vessels and glands. Commonly, fibroblasts express smooth muscle actin, a form of actin first found in smooth muscle cells and not found in resting fibrocytes. Fibroblasts expressing this form of actin are usually called "myo-fibroblasts." Recently, the term "fibrocyte" has also been applied to a blood born cell able to leave the blood, enter tissue and become a fibroblast. As part of the more general topic of stem cell biology, a number of studies have suggested that the blood contains marrow derived cells that can differentiate into fibroblasts. These cells have been reported to express the hematopoietic cell surface markers CD34+, CD45+, as well as as collagen. Chesney J, Bacher M, Bender A, Bucala R. The peripheral blood fibrocyte is a potent antigen-presenting cell capable of priming naive T cells in situ. Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6307-12.] These cell can migrate to wound sites, suggesting a role in wound healing.Abe R, Donnelly SC, Peng T, Bucala R, Metz CN. Peripheral blood fibrocytes: differentiation pathway and migration to wound sites. J Immunol. 2001 Jun 15;166(12):7556-62.] There are several studies suggesting that fibrocytes mediate wound healing and fibrotic tissue repair.Yang L, et al., Peripheral blood fibrocytes from burn patients: identification and quantification of fibrocytes in adherent cells cultured from peripheral blood mononuclear cells. Lab Invest. 2002 Sep;82(9):1183-92.] [Schmidt M, Sun G, Stacey MA, Mori L, Mattoli S. Identification of circulating fibrocytes as precursors of bronchial myofibroblasts in asthma. J Immunol. 2003 Jul 1;171(1):380-9. ] [Moore BB, Kolodsick JE, Thannickal VJ, Cooke K, Moore TA, Hogaboam C, Wilke CA, Toews GB. CCR2-mediated recruitment of fibrocytes to the alveolar space after fibrotic injury. Am J Pathol. 2005 Mar;166(3):675-84. ]

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  • fibrocyte — ● fibrocyte nom masculin Cellule de base du tissu conjonctif. fibrocyte [fibʀɔsit] n. m. ÉTYM. XXe; de fibro , et cyte. ❖ ♦ Biol., histol. Cellule fusiforme du tissu conjonctif indifférencié. ⇒ Fibroblaste. 0 …   Encyclopédie Universelle

  • Fibrocyte — En médecine, un fibrocyte est un fibroblaste au repos, que l on trouve notamment au niveau de la cornée et des tendons. Le fibrocyte peut être provisoirement ou définitivement au repos , on y retrouve les mêmes organites qu au niveau du… …   Wikipédia en Français

  • fibrocyte — n. [L. fibra, thread; Gr. kytos, container] Elongated cells derived from connective tissue cells, the fibroblasts, functioning in the production of fibrous tissue …   Dictionary of invertebrate zoology

  • fibrocyte — Designation sometimes applied to an inactive fibroblast. [fibro + G. kytos, cell] * * * fi·bro·cyte fīb rə .sīt, fib n FIBROBLAST specif a spindle shaped cell of fibrous tissue fi·bro·cyt·ic .fīb rə sit ik, .fib adj * * * n. an inactive cell… …   Medical dictionary

  • fibrocyte — fi·bro·cyte …   English syllables

  • fibrocyte — n. an inactive cell present in fully differentiated connective tissue. It is derived from a fibroblast …   The new mediacal dictionary

  • fibrocyte — …   Useful english dictionary

  • Фиброцит (Fibrocyte) — синтетически неактивная клетка, присутствующая в полностью дифференцированной соединительной ткани. Образуется из фибробласта. Источник: Медицинский словарь …   Медицинские термины

  • ФИБРОЦИТ — (fibrocyte) синтетически неактивная клетка, присутствующая в полностью дифференцированной соединительной ткани. Образуется из фибробласта …   Толковый словарь по медицине

  • fibrocit — FIBROCÍT, fibrocite, s.n. Celulă fundamentală a ţesutului conjunctiv. – Din fr. fibrocyte. Trimis de LauraGellner, 10.05.2004. Sursa: DEX 98  fibrocít s. n. (sil. bro ), pl. fibrocíte Trimis de siveco, 10.08.2004. Sursa: Dicţionar ortografic … …   Dicționar Român

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