Martin Rodbell

Martin Rodbell
Martin Rodbell
Born	December 1, 1925(1925-12-01) Baltimore, Maryland, U.S.
Died	December 7, 1998(1998-12-07) (aged 73) Chapel Hill, North Carolina, U.S.
Residence	United States
Nationality	United States
Fields	Biochemist
Institutions	National Institute of Health
Alma mater	Johns Hopkins University University of Washington
Known for	G-proteins signal transduction
Notable awards	Nobel Prize in Physiology or Medicine (1994) Gairdner Foundation International Award (1984) Richard Lounsbery Award (1987)

Martin Rodbell (December 1, 1925 – December 7, 1998) was an American biochemist and molecular endocrinologist who is best known for his discovery of G-proteins. He shared the 1994 Nobel Prize in Physiology or Medicine with Alfred G. Gilman for "their discovery of G-proteins and the role of these proteins in signal transduction in cells."

Research

Reflecting the increasingly common analogies between computer science and biology in the 1960s, Rodbell believed that the fundamental information processing systems of both computers and biological organisms were similar. He asserted that individual cells were analogous to cybernetic systems made up of three distinct molecular components: discriminators, transducers, and amplifiers (otherwise known as effectors). The discriminator, or cell receptor, receives information from outside the cell; a cell transducer processes this information across the cell membrane; and the amplifier intensifies these signals to initiate reactions within the cell or to transmit information to other cells.

In December 1969 and early:) January 1970, Rodbell was working with a laboratory team that studied the effect of the hormone glucagon on a rat liver membrane receptor--the cellular discriminator that receives outside signals. Rodbell discovered that ATP (adenosine triphosphate) could reverse the binding action of glucagon to the cell receptor and thus dissociate the glucagon from the cell altogether. He then noted that traces of GTP (guanosine triphosphate) could reverse the binding process almost one thousand times faster than ATP. Rodbell deduced that GTP was probably the active biological factor in dissociating glucagon from the cell's receptor, and that GTP had been present as an impurity in his earlier experiments with ATP. This GTP, he found, stimulated the activity in the guanine nucleotide protein (later called the G-protein), which, in turn, produced profound metabolic effects in the cell. This activation of the G-protein, Rodbell postulated, was the "second messenger" process that Earl W. Sutherland had theorized. In the language of signal transduction, the G-protein, activated by GTP, was the principal component of the transducer, which was the crucial link between the discriminator and the amplifier. Later, Rodbell postulated, and then provided evidence for, additional G-proteins at the cell receptor that could inhibit and activate transduction, often at the same time. In other words, cellular receptors were sophisticated enough to have several different processes going on simultaneously.

Biography

Rodbell was born in Baltimore, Maryland. After graduating from the Baltimore City College high school, he entered Johns Hopkins University in 1943, with interests in biology and French existential literature. In 1944, his studies were interrupted by his military service as a U.S. Navy radio operator during World War II. He returned to Hopkins in 1946 and received his B.S. in biology in 1949. In 1950, he married Barbara Ledermann, a former friend of the legendary diarist Anne Frank, with whom he had four children. Rodbell received his Ph.D. in biochemistry at the University of Washington in 1954. He did post-doctoral work at the University of Illinois at Urbana-Champaign from 1954 to 1956. In 1956, Rodbell accepted a position as a research biochemist at the National Heart Institute, part of the National Institutes of Health, in Bethesda, Maryland. In 1985, Rodbell became Scientific Director of the NIH's National Institute of Environmental Health Sciences in Research Triangle Park, North Carolina where he worked until his retirement in 1994. He died in Chapel Hill of multiple organ failure after an extended illness.

This article contains text from the website of the NIH, part of the U.S. Government, and thus under public domain

His Scientific Quest

Rodbell concluded his formal written Nobel Lecture^[1] with this Poem:

To my Friends:Thoughts from “On High”

Life on a roller coaster, oscillating from hither to yon,
no respite for the iconoclast, wandering from dusk to dawn.
Conjuring strange thoughts foreign and twice forbidden,
like Prometheus unbound, this Nobelist climbs in vain
to Andean peaks, seeking what most would proclaim insane.
Why, he ponders, are there no answers to protean questions
when others thinking cleanly and simply with Occam’s sharp razor
proclaim what seems obvious given the beam of their unerring laser.
Nature, happily unfettered with philosophy, or with cunning, or with intent
moves relentlessly onward or even backward with energy unspent
while we mortals test and probe with twinkling machines blinking precisely
at each movement, striving to unravel its irresolute randomness, its fathomless,
unlimited, meaningless rush into spiraling chaos,
oblivious of its multitudinous trials & errors which we pontifically believe
must be unerring truth & resolution.

The laugh is on those who, burdened with pretensions of truth, believe they
can fathom within 15 minutes of human existence what has transpired over
eons of space and time in this Universe .
So, I extol the intuitions encapsulated in the folds of my mind
from whence occasionally they hurtle to the forebrain and in a twinkling of
a proton’s discharge bring to fruition a thought, an idea borne on the feathery
appendages of teeming neurons wedded in a seamless synergy. Those
fleeting moments are cherished as are those precious impulses imparted by
the innumerable individuals who nurtured and instilled unknowingly their
encrypted thoughts in mine.

So, with these fanciful thoughts in mind I give praise to you - my friends, my
colleagues, my soul-mates, my loved ones - for letting my soul and thoughts
meander hither and yonder in this attempt at philosophy and poetry. We
now belong to the Gods on high who praise us for our frailties and our
achievements.

References

1. ^ Nobel Lecture

• Raju, T N (June 2000). "The Nobel chronicles. 1994: Alfred G Gilman (b 1941) and Martin Rodbell (1925-98)". Lancet (England) 355 (9222): 2259. ISSN 0140-6736. PMID 10881927. 
• Birnbaumer, L (March 1999). "Martin Rodbell (1925-1998)". Science (United States) 283 (5408): 1656. doi:10.1126/science.283.5408.1656. PMID 10189319. 
• Svoboda, P (June 1995). "[The Nobel Prize for physiology and medicine 1994. Alfred G. Gilman and Martin Rodbell--the role of GTP-binding proteins in signal transfer in the interior of cells]". Cas. Lek. Cesk. (Czech Republic) 134 (13): 415–7. ISSN 0008-7335. PMID 7671286. 
• Schultz, G (March 1995). "Nobel Prize 1994 for medicine/physiology". J. Mol. Med. (Germany) 73 (3): 121–2. doi:10.1007/BF00198239. PMID 7633948. 
• Kurlandzka, A; Fronk J (1995). "[Nobel prize 1994 -- G proteins]". Postepy Biochem. (Poland) 41 (1): 3–4. ISSN 0032-5422. PMID 7777431. 
• Bogucki, W M (1995). "[Nobel prize in physiology and medicine in the year 1994]". Pneumonologia i alergologia polska : organ Polskiego Towarzystwa Ftyzjopneumonologicznego, Polskiego Towarzystwa Alergologicznego, i Instytutu Gruźlicy i Chorób Płuc (Poland) 63 (1–2): 120–2. ISSN 0867-7077. PMID 7633362. 
• Flawia, M M (1995). "[Nobel Prize in medicine 1994: Martín Rodbell and Alfred Gilman. Signal transduction]". Medicina (B Aires) (Argentina) 55 (1): 75–80. ISSN 0025-7680. PMID 7565041. 
• Blum, H E (December 1994). "[The Nobel Prize for Medicine 1994]". Dtsch. Med. Wochenschr. (Germany) 119 (51–52): 1792–5. doi:10.1055/s-0029-1235137. ISSN 0012-0472. PMID 7736935. 
• Farfel, Z (December 1994). "[Nobel Prize winners in Medicine 1994]". Harefuah (Israel) 127 (12): 530–1. ISSN 0017-7768. PMID 7813930. 
• Fredholm, B B; Aperia A (December 1994). "[The 1994 Nobel Prize: discovery and significance of G-proteins]". Ugeskr. Laeg. (Denmark) 156 (50): 7520–4. ISSN 0041-5782. PMID 7839516. 
• Christoffersen, T (December 1994). "[The 1994 Nobel Prize in physiology and medicine. Signal transduction and g-proteins]". Tidsskr. Nor. Laegeforen. (Norway) 114 (30): 3562–3. ISSN 0029-2001. PMID 7825126. 
• Lefkowitz, R J (December 1994). "Rodbell and Gilman win 1994 Nobel Prize for Physiology and Medicine". Trends Pharmacol. Sci. (England) 15 (12): 442–4. doi:10.1016/0165-6147(94)90053-1. PMID 7886813. 
• Krans, H M (November 1994). "[The 1994 Nobel Prize for Medicine for the discovery of G-protein]". Nederlands tijdschrift voor geneeskunde (Netherlands) 138 (48): 2380–2. ISSN 0028-2162. PMID 7990983. 
• Marx, J (October 1994). "Nobel Prizes. Medicine: a signal award for discovering G proteins". Science (United States) 266 (5184): 368–9. doi:10.1126/science.7939678. PMID 7939678. 
• Fredholm, B B; Aperia A (October 1994). "[Nature's solution of the communication problem resulted in Nobel Prize. Significance of G-proteins for signal transmission in cells]". Lakartidningen (Sweden) 91 (42): 3811–7. ISSN 0023-7205. PMID 7996951. 
• Coles, H (October 1994). "Nobel honours pursuit of G proteins". Nature (England) 371 (6498): 547. doi:10.1038/371547b0. PMID 7935774. 
• Lakso, M; Wong G (1994). "[Nobel Prize to a supporter of young scientists]". Duodecim; lääketieteellinen aikakauskirja (Finland) 110 (23–24): 2184–6. ISSN 0012-7183. PMID 8654237. 
• Rodbell, M (December 1991). "The beginnings of an endocrinologist". Endocrinology (United States) 129 (6): 2807–8. doi:10.1210/endo-129-6-2807. ISSN 0013-7227. PMID 1954866. 

See also

• List of Jewish Nobel laureates

External links

• Nobel Prize Biography
• Martin Rodbell Papers (1925-1999) - National Library of Medicine finding aid
• The Martin Rodbell Papers - Profiles in Science, National Library of Medicine

Persondata
Name	Rodbell, Martin
Alternative names
Short description
Date of birth	December 1, 1925
Place of birth	Baltimore, Maryland, U.S.
Date of death	December 7, 1998
Place of death	Chapel Hill, North Carolina, U.S.