Fate mapping

Fate mapping

Fate mapping is a that is used to show how a cell or tissue moves and what it will become during normal development. Fate mapping was developed by Walter Vogt as a means by which to trace the development of specific regions of the early embryo. To do this, Vogt used agar chips impregnated with vital dyes.

A fate map is a representation of the developmental history of each cell in the body of an adult organism. Thus, a fate map traces the products of each mitosis from the single-celled zygote to the multi-celled adult. The process of fate mapping was developed by Walter Vogt.

The fate map of vulval development in C. elegans has been completely characterized at a molecular level. In an adult C. elegans, the vulva is the egg-laying organ that consists of only 22 cells. The differentiation and division of these Px.p cells is dictated by the anchor cell through a morphogen gradient of LIN-3. Mapping each cell's fate was accomplished by studying mutants and through tissue grafts.

External links

*http://worms.zoology.wisc.edu/frogs/gast/gast_fatemap.html

* [http://www.cshprotocols.org/cgi/content/full/2007/24/pdb.prot4915 Fate-Mapping Technique: Using Carbocyanine Dyes for Vital Labeling of Cells in Gastrula-Stage Mouse Embryos Cultured in Vitro]


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