Diiodotyrosine

Diiodotyrosine
Diiodotyrosine
Identifiers
CAS number 66-02-4
PubChem 6181
UNII 6L57Q44ZWW YesY
MeSH Diiodotyrosine
Properties
Molecular formula C9H9I2NO3
Molar mass 432.982 g/mol
 YesY (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Diiodotyrosine (DIT) is a precursor of thyroid hormone and results from iodization of monoiodotyrosine at the other meta- position on the phenol ring.

DIT is a modulator of thyroid peroxidase.[1] When combined with monoiodotyrosine in the colloid of the thyroid follicle, triiodothyronine is formed. Two molecules of DIT combine to make thyroxine.

See also

References

  1. ^ Dème D, Fimiani E, Pommier J, Nunez J (February 1975). "Free diiodotyrosine effects on protein iodination and thyroid hormone synthesis catalyzed by thyroid peroxidase". Eur. J. Biochem. 51 (2): 329–36. doi:10.1111/j.1432-1033.1975.tb03932.x. PMID 1149735. http://www3.interscience.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0014-2956&date=1975&volume=51&issue=2&spage=329. 

External links

v · d · eThyroid therapy (H03)
Thyroid hormones
Antithyroid preparations
Block conversion of
T4 to T3
Other
Diiodotyrosine • Dibromotyrosine

M: END

anat/phys/devp/horm

noco(d)/cong/tumr, sysi/epon

proc, drug (A10/H1/H2/H3/H5)
v · Thyroid hormone metabolic intermediates
Tyrosine / iodotyrosine
Monoiodotyrosine · Diiodotyrosine
Thyronine / iodothyronine
Thyronamine / iodothyronamine
3-Iodothyronamine · 3,3',5-Triiodothyronamine

M: MET

mt, k, c/g/r/p/y/i, f/h/s/l/o/e, a/u, n, m

k, cgrp/y/i, f/h/s/l/o/e, au, n, m, epon

m(A16/C10),i(k, c/g/r/p/y/i, f/h/s/o/e, a/u, n, m)

M: END

anat/phys/devp/horm

noco(d)/cong/tumr, sysi/epon

proc, drug (A10/H1/H2/H3/H5)


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