Frizzled

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Symbol = Frizzled
Name = Frizzled/Smoothened family membrane region


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Pfam= PF01534
InterPro= IPR000539
SMART=
PROSITE = PDOC50038
SCOP =
TCDB =
OPM family=
OPM protein=
PDB=

Frizzled is a family of G protein-coupled receptor proteinscite journal | author = Malbon CC | title = Frizzleds: new members of the superfamily of G-protein-coupled receptors | journal = Front. Biosci. | volume = 9 | issue = | pages = 1048–58 | year = 2004 | pmid = 14977528 | doi = 10.2741/1308 | issn = ] that serve as receptors in the Wnt signaling pathway and other signaling pathways. When activated, Frizzled leads to activation of Dishevelled in the cytosol. Frizzled proteins and the genes that encode them have been identified in an array of animals, from sponges to humans. Frizzled proteins also play key roles in governing cell polarity, embryonic development, formation of neural synapses, cell proliferation, and many other processes in developing and adult organisms.cite journal | author = Huang HC, Klein PS | title = The Frizzled family: receptors for multiple signal transduction pathways | journal = Genome Biol. | volume = 5 | issue = 7 | pages = 234 | year = 2004 | pmid = 15239825 | doi = 10.1186/gb-2004-5-7-234 | issn = ] Mutations in the human frizzled-4 receptor have been linked to familial exudative vitreoretinopathy, a rare disease affecting the retina at the back of the eye, and the vitreous, the clear fluid inside the eye.

The frizzled (fz) locus of Drosophila coordinates the cytoskeletons of epidermal cells, producing a parallel array of cuticular hairs and bristlescite journal |author=Adler PN, Vinson C, Park WJ, Conover S, Klein L |title=Molecular structure of frizzled, a Drosophila tissue polarity gene |journal=Genetics |volume=126 |issue=2 |pages=401–416 |year=1990 |pmid=2174014] cite journal |author=Adler PN, Conover S, Vinson CR |title=A Drosophila tissue polarity locus encodes a protein containing seven potential transmembrane domains |journal=Nature |volume=338 |issue=6212 |pages=263–264 |year=1989 |pmid=2493583 |doi=10.1038/338263a0] . In fz mutants, the orientation of individual hairs with respect both to their neighbours and to the organism as a whole is altered. In the wild-type wing, all hairs point towards the distal tip.

In the developing wing, Fz has 2 functions: it is required for the proximal-distal transmission of an intracellular polarity signal; and it is required for cells to respond to the polarity signal. Fz produces an mRNA that encodes an integral membrane protein with 7 putative transmembrane (TM) domains. This protein should contain both extracellular and cytoplasmic domains, which could function in the transmission and interpretation of polarity informationcite journal |author=Adler PN, Conover S, Vinson CR |title=A Drosophila tissue polarity locus encodes a protein containing seven potential transmembrane domains |journal=Nature |volume=338 |issue=6212 |pages=263–264 |year=1989 |pmid=2493583 |doi=10.1038/338263a0] . This signature is usually found downstream of the Fz domain (InterPro|IPR000024)

Group members

The following is a list of the ten known human frizzled receptors:

* FZD1 (Gene|FZD1)
* FZD2 (Gene|FZD2)
* FZD3 (Gene|FZD3)
* FZD4 (Gene|FZD4)
* FZD5 (Gene|FZD5)
* FZD6 (Gene|FZD6)
* FZD7 (Gene|FZD7)
* FZD8 (Gene|FZD8)
* FZD9 (Gene|FZD9)
* FZD10 (Gene|FZD10)

ee also

* Smoothened

External links

* [http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1504 IUPHAR GPCR Database - Frizzled receptor family]
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References