Adenosine diphosphate

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CASNo=58-64-0
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SMILES=Nc1ncnc2 [n] (cnc12) [C@@H] 3O [C@H]
(COP( [O-] )(=O)OP(O)( [O-] )=O)C(O)C3O
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Formula=C₁₀H₁₅N₅O₁₀P₂
MolarMass=427.201
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Adenosine diphosphate, abbreviated ADP, is a nucleotide. It is an ester of pyrophosphoric acid with the nucleoside adenosine. ADP consists of the pyrophosphate group, the pentose sugar ribose, and the nucleobase adenine.

ADP is the product of ATP dephosphorylation by ATPases. ADP is converted back to ATP by ATP synthases. ATP is an important energy transfer molecule in cells.

ADP is stored in dense bodies inside blood platelets and is released upon platelet activation. ADP interacts with a family of ADP receptors found on platelets (P2Y1, P2Y12 and P2X1), leading to further platelet activation. [Murugappa S, Kunapuli SP, "The role of ADP receptors in platelet function", "Front Biosci.", 2006, 11:1977-86] ADP in the blood is converted to adenosine by the action of ecto-ADPases, inhibiting further platelet activation via adenosine receptors. The anti-platelet drug Plavix (clopidogrel) inhibits the P2Y12 receptor.

ADP is the end-product that results when ATP loses one of its phosphate groups located at the end of the molecule. [Nave, C.R. Adenosine Triphosphate. Georgia State University: Hyper Physics [serial on the Internet] . 2005 [cited 2007 December 7] . Available from:http://hyperphysics.phy-astr.gsu.edu/hbase/biology/atp.html] The conversion of these two molecules plays a critical role in supplying energy for many processes of life. [Nave, C.R. Adenosine Triphosphate. Georgia State University: Hyper Physics [serial on the Internet] . 2005 [cited 2007 December 7] . Available from:http://hyperphysics.phy-astr.gsu.edu/hbase/biology/atp.html] The deletion of one of ATP’s phosphorous bonds generates about the same amount of energy derived from human digestion of a single peanut, approximately 7.3 kilocalories per Mole of ATP. [Farabee, M.J. The Nature of ATP. ATP and Biological Energy [serial on the Internet] . 2002 [cited 2007 December 7] . Available from:http://www.emc.maricopa.edu/faculty/farabee/BIOBK/BioBookATP.html] ADP can be converted, or powered back to ATP through the process of releasing the chemical energy available in food; in humans this is constantly performed via aerobic respiration in the mitochondria. [Nave, C.R. Adenosine Triphosphate. Georgia State University: Hyper Physics [serial on the Internet] . 2005 [cited 2007 December 7] . Available from:http://hyperphysics.phy-astr.gsu.edu/hbase/biology/atp.html] Plants use photosynthetic pathways to convert and store the energy from sunlight, via conversion of ADP to ATP. [Farabee, M.J. The Nature of ATP. ATP and Biological Energy [serial on the Internet] . 2002 [cited 2007 December 7] . Available from:http://www.emc.maricopa.edu/faculty/farabee/BIOBK/BioBookATP.html] Animals use the energy released in the breakdown of glucose and other molecules to convert ADP to ATP, which can then be used to fuel necessary growth and cell maintenance. [Nave, C.R. Adenosine Triphosphate. Georgia State University: Hyper Physics [serial on the Internet] . 2005 [cited 2007 December 7] . Available from:http://hyperphysics.phy-astr.gsu.edu/hbase/biology/atp.html]

See also

* Nucleoside
* Nucleotide
* DNA
* RNA
* Oligonucleotide
* Adenosine triphosphate
* Apyrase

References

External links