Transcription Factor II H

protein
Name= general transcription factor IIH, polypeptide 1, 62kDa
caption=


width=
HGNCid=4655
Symbol=GTF2H1
AltSymbols= BTF2
EntrezGene=2965
OMIM=189972
RefSeq=NM_005316
UniProt=P32780
PDB=
ECnumber=
Chromosome=11
Arm=p
Band=15.1
LocusSupplementaryData=-p14protein
Name=general transcription factor IIH, polypeptide 2, 44kDa
caption=


width=
HGNCid=4656
Symbol=GTF2H2
AltSymbols=BTF2, TFIIH, BTF2P44, T-BTF2P44
EntrezGene=2966
OMIM=601748
RefSeq=NM_001515
UniProt=Q13888
PDB=
ECnumber=
Chromosome=5
Arm=q
Band=12.2
LocusSupplementaryData=-13.3protein
Name=general transcription factor IIH, polypeptide 3, 34kDa
caption=


width=
HGNCid=4657
Symbol=GTF2H3
AltSymbols=BTF2, TFIIH
EntrezGene=2967
OMIM=601750
RefSeq=NM_001516
UniProt=Q13889
PDB=
ECnumber=
Chromosome=12
Arm=q
Band=24.31
LocusSupplementaryData=

Transcription Factor II H (TFIIH) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex. TFIIH contains a number of subunits with different functions.cite journal | author = Lee TI, Young RA | title = Transcription of eukaryotic protein-coding genes | journal = Annu. Rev. Genet. | volume = 34 | issue = | pages = 77–137 | year = 2000 | pmid = 11092823 | doi = 10.1146/annurev.genet.34.1.77] Two of the subunits, ERCC2/XPD and ERCC3/XPB, have helicase and ATPase activities and help create the transcription bubble. In a test tube these subunits are only required for transcription if the DNA template is not already denatured or supercoiled. Two other TFIIH subunits, CDK7 and cyclin H, phosphorylate serine amino acids on the RNA polymerase II C-terminal domain and possibly other proteins involved in the cell cycle.

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