Aurora B kinase

Aurora B kinase

Aurora B kinase is a human protein that functions in the attachment of the mitotic spindle to the centromere. PBB_Summary
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summary_text = Chromosomal segregation during mitosis as well as meiosis is regulated by kinases and phosphatases. The Aurora kinases associate with microtubules during chromosome movement and segregation. Aurora kinase B localizes to microtubules near kinetochores, specifically to the specialized microtubules called K-fibers, and Aurora kinase A (MIM 603072) localizes to centrosomes (Lampson et al., 2004). [supplied by OMIM] cite web | title = Entrez Gene: AURKB aurora kinase B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9212| accessdate = ] In cancerous cells, over expression of these enzymes cause unequal distribution of genetic information creating aneuploidy cells, a hallmark of cancer.

References

Further reading

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citations =
*cite journal | author=Nigg EA |title=Mitotic kinases as regulators of cell division and its checkpoints. |journal=Nat. Rev. Mol. Cell Biol. |volume=2 |issue= 1 |pages= 21–32 |year= 2001 |pmid= 11413462 |doi= 10.1038/35048096
*cite journal | author=Shindo M, Nakano H, Kuroyanagi H, "et al." |title=cDNA cloning, expression, subcellular localization, and chromosomal assignment of mammalian aurora homologues, aurora-related kinase (ARK) 1 and 2. |journal=Biochem. Biophys. Res. Commun. |volume=244 |issue= 1 |pages= 285–92 |year= 1998 |pmid= 9514916 |doi= 10.1006/bbrc.1998.8250
*cite journal | author=Tatsuka M, Katayama H, Ota T, "et al." |title=Multinuclearity and increased ploidy caused by overexpression of the aurora- and Ipl1-like midbody-associated protein mitotic kinase in human cancer cells. |journal=Cancer Res. |volume=58 |issue= 21 |pages= 4811–6 |year= 1998 |pmid= 9809983 |doi=
*cite journal | author=Kimura M, Matsuda Y, Yoshioka T, "et al." |title=Identification and characterization of STK12/Aik2: a human gene related to aurora of Drosophila and yeast IPL1. |journal=Cytogenet. Cell Genet. |volume=82 |issue= 3-4 |pages= 147–52 |year= 1999 |pmid= 9858806 |doi=10.1159/000015089
*cite journal | author=Katayama H, Ota T, Morita K, "et al." |title=Human AIM-1: cDNA cloning and reduced expression during endomitosis in megakaryocyte-lineage cells. |journal=Gene |volume=224 |issue= 1-2 |pages= 1–7 |year= 1999 |pmid= 9931403 |doi=10.1016/S0378-1119(98)00522-8
*cite journal | author=Prigent C, Gill R, Trower M, Sanseau P |title=In silico cloning of a new protein kinase, Aik2, related to Drosophila Aurora using the new tool: EST Blast. |journal=In Silico Biol. (Gedrukt) |volume=1 |issue= 2 |pages= 123–8 |year= 2001 |pmid= 11471245 |doi=
*cite journal | author=Wheatley SP, Carvalho A, Vagnarelli P, Earnshaw WC |title=INCENP is required for proper targeting of Survivin to the centromeres and the anaphase spindle during mitosis. |journal=Curr. Biol. |volume=11 |issue= 11 |pages= 886–90 |year= 2001 |pmid= 11516652 |doi=10.1016/S0960-9822(01)00238-X
*cite journal | author=Zeitlin SG, Shelby RD, Sullivan KF |title=CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis. |journal=J. Cell Biol. |volume=155 |issue= 7 |pages= 1147–57 |year= 2002 |pmid= 11756469 |doi= 10.1083/jcb.200108125
*cite journal | author=Crosio C, Fimia GM, Loury R, "et al." |title=Mitotic phosphorylation of histone H3: spatio-temporal regulation by mammalian Aurora kinases. |journal=Mol. Cell. Biol. |volume=22 |issue= 3 |pages= 874–85 |year= 2002 |pmid= 11784863 |doi=
*cite journal | author=Goto H, Yasui Y, Nigg EA, Inagaki M |title=Aurora-B phosphorylates Histone H3 at serine28 with regard to the mitotic chromosome condensation. |journal=Genes Cells |volume=7 |issue= 1 |pages= 11–7 |year= 2002 |pmid= 11856369 |doi=10.1046/j.1356-9597.2001.00498.x
*cite journal | author=Gigoux V, L'Hoste S, Raynaud F, "et al." |title=Identification of Aurora kinases as RasGAP Src homology 3 domain-binding proteins. |journal=J. Biol. Chem. |volume=277 |issue= 26 |pages= 23742–6 |year= 2002 |pmid= 11976319 |doi= 10.1074/jbc.C200121200
*cite journal | author=Sugiyama K, Sugiura K, Hara T, "et al." |title=Aurora-B associated protein phosphatases as negative regulators of kinase activation. |journal=Oncogene |volume=21 |issue= 20 |pages= 3103–11 |year= 2002 |pmid= 12082625 |doi= 10.1038/sj.onc.1205432
*cite journal | author=Chen J, Jin S, Tahir SK, "et al." |title=Survivin enhances Aurora-B kinase activity and localizes Aurora-B in human cells. |journal=J. Biol. Chem. |volume=278 |issue= 1 |pages= 486–90 |year= 2003 |pmid= 12419797 |doi= 10.1074/jbc.M211119200
*cite journal | author=Morrison C, Henzing AJ, Jensen ON, "et al." |title=Proteomic analysis of human metaphase chromosomes reveals topoisomerase II alpha as an Aurora B substrate. |journal=Nucleic Acids Res. |volume=30 |issue= 23 |pages= 5318–27 |year= 2002 |pmid= 12466558 |doi=10.1093/nar/gkf665
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Kawajiri A, Yasui Y, Goto H, "et al." |title=Functional significance of the specific sites phosphorylated in desmin at cleavage furrow: Aurora-B may phosphorylate and regulate type III intermediate filaments during cytokinesis coordinatedly with Rho-kinase. |journal=Mol. Biol. Cell |volume=14 |issue= 4 |pages= 1489–500 |year= 2003 |pmid= 12686604 |doi= 10.1091/mbc.E02-09-0612
*cite journal | author=Minoshima Y, Kawashima T, Hirose K, "et al." |title=Phosphorylation by aurora B converts MgcRacGAP to a RhoGAP during cytokinesis. |journal=Dev. Cell |volume=4 |issue= 4 |pages= 549–60 |year= 2003 |pmid= 12689593 |doi=10.1016/S1534-5807(03)00089-3
*cite journal | author=Honda R, Körner R, Nigg EA |title=Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis. |journal=Mol. Biol. Cell |volume=14 |issue= 8 |pages= 3325–41 |year= 2004 |pmid= 12925766 |doi= 10.1091/mbc.E02-11-0769
*cite journal | author=Tien AC, Lin MH, Su LJ, "et al." |title=Identification of the substrates and interaction proteins of aurora kinases from a protein-protein interaction model. |journal=Mol. Cell Proteomics |volume=3 |issue= 1 |pages= 93–104 |year= 2004 |pmid= 14602875 |doi= 10.1074/mcp.M300072-MCP200

External links

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