- CC chemokine receptors
protein
Name =CCR1
caption =
width =
HGNCid =1602
Symbol = CCR1
AltSymbols =
EntrezGene = 1230
OMIM = 601159
RefSeq = NM_001295
UniProt = P32246
PDB =
ECnumber =
Chromosome = 3
Arm = p21
Band =
LocusSupplementaryData =protein
Name =CCR2
caption =
width =
HGNCid =1603
Symbol = CCR2
AltSymbols =
EntrezGene = 1231
OMIM = 601268
RefSeq = NM_000647
UniProt = P41597
PDB = 1KAD
ECnumber =
Chromosome = 3
Arm = p21
Band =
LocusSupplementaryData =protein
Name = CCR3
caption =
width =
HGNCid =1604
Symbol = CCR3
AltSymbols =
EntrezGene = 1232
OMIM = 601268
RefSeq = NM_001837
UniProt = P51677
PDB =
ECnumber =
Chromosome = 3
Arm = p21
Band =
LocusSupplementaryData =protein
Name =CCR4
caption =
width =
HGNCid =1605
Symbol = CCR4
AltSymbols =
EntrezGene = 1233
OMIM = 604836
RefSeq = NM_005508
UniProt = P51679
PDB =
ECnumber =
Chromosome = 3
Arm = p24
Band =
LocusSupplementaryData =protein
Name =CCR5
caption =
width =
HGNCid =1606
Symbol = CCR5
AltSymbols =
EntrezGene = 1234
OMIM = 601373
RefSeq = NM_000579
UniProt = P51681
PDB = 1ND8
ECnumber =
Chromosome = 3
Arm = p21
Band =
LocusSupplementaryData =protein
Name =CCR6
caption =
width =
HGNCid =1607
Symbol = CCR6
AltSymbols =
EntrezGene = 1235
OMIM = 601835
RefSeq = NM_004367
UniProt = P51684
PDB =
ECnumber =
Chromosome = 6
Arm = q27
Band =
LocusSupplementaryData =protein
Name =CCR7
caption =
width =
HGNCid =1608
Symbol = CCR7
AltSymbols =
EntrezGene = 1236
OMIM = 600242
RefSeq = NM_001838
UniProt = P32248
PDB =
ECnumber =
Chromosome = 17
Arm = q12-q21.2
Band =
LocusSupplementaryData =protein
Name =CCR8
caption =
width =
HGNCid =1609
Symbol = CCR8
AltSymbols =
EntrezGene = 1237
OMIM = 601834
RefSeq = NM_005201
UniProt = P51685
PDB =
ECnumber =
Chromosome = 3
Arm = p22
Band =
LocusSupplementaryData =protein
Name =CCR9
caption =
width =
HGNCid =1610
Symbol = CCR9
AltSymbols =
EntrezGene = 10803
OMIM = 604738
RefSeq = NM_031200
UniProt = P51686
PDB =
ECnumber =
Chromosome = 3
Arm = p21
Band =
LocusSupplementaryData =protein
Name =CCR10
caption =
width =
HGNCid =4474
Symbol = CCR10
AltSymbols =
EntrezGene = 2826
OMIM = 600240
RefSeq = NM_016602
UniProt = P46092
PDB =
ECnumber =
Chromosome = 17
Arm = 17q21.1-q21
Band =
LocusSupplementaryData =CC chemokine receptors are
integral membrane protein s that specifically bind and respond tocytokine s of the CC chemokine family. They represent one subfamily ofchemokine receptor s, a large family of G protein-linked receptors that are known as seven transmembrane (7-TM) proteins since they span the cell membrane seven times. To date, ten true members of the CC chemokine receptor subfamily have been described. These are named CCR1 to CCR10 according to the IUIS/WHO Subcommittee on Chemokine Nomenclature.Mechanism
The CC chemokine receptors all work by activating the
G protein Gi [ [http://senselab.med.yale.edu/NeuronDB/receptors2.asp#Chemokine%20receptors,CC senselab] ] .Types
Overview table
CCR1
CCR1 was the first CC chemokine receptor identified and binds multipleinflammatory /inducible (seeinducible gene ) CC chemokines (includingCCL4 ,CCL5 ,CCL6 ,CCL14 ,CCL15 ,CCL16 andCCL23 ). [Ma et al. The C10/CCL6 chemokine and CCR1 play critical roles in the pathogenesis of IL-13-induced inflammation and remodeling. J Immunol. 2004 Feb 1;172(3):1872-81.] Youn et al Molecular cloning of leukotactin-1: a novel human beta-chemokine, a chemoattractant for neutrophils, monocytes, and lymphocytes, and a potent agonist at CC chemokine receptors 1 and 3. J. Immun. 159: 5201-5205, 1997.] Nomiyama et al. Human CC chemokine liver-expressed chemokine/CCL16 is a functional ligand for CCR1, CCR2 and CCR5, and constitutively expressed by hepatocytes. Int Immunol. 2001 Aug;13(8):1021-9.] [Berahovich et al. Proteolytic Activation of Alternative CCR1 Ligands in Inflammation. J. Immunol. 174:7341-7351, 2005.] In humans, this receptor can be found onperipheral blood lymphocytes andmonocytes . There is some suggestion that this chemokine receptor is restricted tomemory T-cells within thelymphocyte pool. This receptor is also designatedcluster of differentiation marker CD191.CCR2
CCR2 can interact withCCL2 ,CCL8 andCCL16 and has been identified on the surface ofmonocytes , activatedmemory T cells ,B cells , andbasophils in humans, and also inperitoneal macrophages in mice.Ogilvie et al. Eotaxin is a natural antagonist for CCR2 and an agonist for CCR5. Blood. 2001, 97:1920-4 ] CCR2 is also designated CD192.CCR3
CCR3 is a receptor for multiple inflammatory/inducible CC chemokines, including
CCL11 ,CCL26 ,CCL7 ,CCL13 ,CCL15 ,CCL24 andCCL5 that attracteosinophils , andCCL28 that attracts B and Tlymphocyte s tomucosal tissue s. [Kitaura et al. Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3. J. Biol. Chem. 1996, 271:7725-7730.] [Kitaura et al. Molecular cloning of a novel human CC chemokine (Eotaxin-3) that is a functional ligand of CC chemokine receptor 3. J. Biol. Chem. 274:27975-27980, 1999.] Pan et al. 2000, A novel chemokine ligand for CCR10 and CCR3 expressed by epithelial cells in mucosal tissues, J. Immunol. 165: 2943–2949.] [White et al. Cloning and functional characterization of a novel human CC chemokine that binds to the CCR3 receptor and activates human eosinophils. J. Leukoc. Biol. 62:667-675, 1997.] It is most highly expressed in botheosinophils andbasophils , but can also be found inTh1 andTh2 cells and airwayepithelial cells . Thus CCR3 plays a role in allergic reactions. CCR3 is also known asCD193 .CCR4
CCR4 is expressed on Th2T lymphocytes and is up-regulated byT cell receptor activation. However, some reports suggest a role for this receptor also in trafficking ofdendritic cells . The CC chemokinesCCL3 ,CCL5 ,CCL17 andCCL22 signal through this receptor. [Imai et al. The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4. J. Biol. Chem. 272: 15036-15042, 1997. ] [Imai et al. Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4. J. Biol. Chem. 273:1764-1768 (1998).]CCR5
CCR5 is expressed on several cell types including peripheral blood-deriveddendritic cells , CD34+hematopoietic progenitor cells and certain activated/memory Th1 lymphocytes. This receptor is well defined as a major coreceptor implicated in susceptibility toHIV-1 infection and disease. This receptor has several CC chemokine ligands includingCCL2 ,CCL3 ,CCL4 ,CCL5 ,CCL11 ,CCL13 ,CCL14 andCCL16 . [Gong et al., Monocyte Chemotactic Protein-2 Activates CCR5 and Blocks CD4/CCR5-mediated HIV-1 Entry/Replication. J Biol Chem, 1998, 273,4289-4292.] [Blanpain et al., CCR5 binds multiple CC-chemokines: MCP-3 acts as a natural antagonist. Blood. 1999, 94:1899-905.]CCR6
CCR6 , a receptor forCCL20 , is expressed on unactivatedmemory T-cells and somedendritic cells . CCR6 is also expressed on Th17 cells. [Acosta-Rodriguez et al., Surface phenotype and antigenic specificity of human interleukin 17–producing T helper memory cells. Nat. Immunology, 2007, 6, 639-646.] CCR6 is down-regulated in activated T-cells. [Baba et al., Identification of CCR6, the specific receptor for a novel lymphocyte-directed CC chemokine LARC. J Biol Chem. 1997, 272:14893-8.]CCR7
CCR7 is a highly important receptor with a role in trafficking of B and T lymphocytes anddendritic cells to and acrosshigh endothelial venules and positioning those cells correctly in T cell zones of secondarylymphoid organs . Its ligands include the related chemokinesCCL19 andCCL21 , (previously called ELC and SLC). [Yoshida et al. Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific ligand for EBI1, CCR7. J. Biol. Chem. 272: 13803-13809, 1997. ]CCR8
CCR8 is associated with Th2 lymphocytes and is therefore found predominantly in thethymus (in humans) although some expression can be found in the brain,spleen ,lymph node , and monocytes at thenucleotide level. The ligands for this receptor areCCL1 andCCL16 . [Roos et al., Identification of CCR8, the receptor for the human CC chemokine I-309. J Biol Chem 1997 Vol 272, 17251–4. ]CCR9
CCR9 was previously calledorphan receptor GPR 9-6 and is very highly expressed in thymus (on both immature and mature T-cells) while low in lymph nodes and spleen. CCR9 is also abundant in the gut, with its expression associated with T cells of theintestine . The specific ligand of this receptor isCCL25 . [Zaballos et al., Identification of the orphan chemokine receptor GPR-9-6 as CCR9, the receptor for the chemokine TECK. J. Immunol., 1999, 162:5671-5675.] To note, the chemokine binding protein D6 had previously been named CCR9, but this molecule is ascavenger receptor not a true (signaling) chemokine receptor.CCR10
CCR10 is receptor forCCL27 andCCL28 that was originally called orphan receptor GPR2. [Gosling et al., Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK. J Immunol. 2000, 164:2851-6.] [Homey et al. The orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC). J. Immunol. 164:3465-3470, 2000.] [Wang et al. 2000, Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2). J. Biol. Chem. 275: 22313–22323.] CCR10 has been implicated in inflammation of the skin, and has been shown to recruitregulatory T cells (Tregs ) to mucosal layers.CCR11
This molecule was originally designated CCR11 due to its ability to bind several CC chemokines (including
CCL19 ,CCL21 andCCL25 ) and its structural similarity to chemokine receptors. However, due to the inability of this molecule (also known asCCRL1 and CCX CKR) to generate a signal following ligand interaction, it has been suggested that it is a scavenger receptor for chemokines and not a bonafide chemokine receptor. Thus CCRL1 should not be called CCR11 under the guidelines of the IUIS/WHO Subcommittee on Chemokine Nomenclature.References
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