Integrin-linked kinase

Integrin-linked kinase (ILK) is a 59kDa protein originally identified while conducting a yeast-two hybrid screen with integrin β1 as the bait protein (Hannigan et al., 1996). Since its discovery, ILK has been associated with multiple cellular functions including cell migration, cell proliferation, cell-adhesions, signal transduction

PBB_Summary
section_title =
summary_text = Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. This gene encodes a serine/threonine protein kinase with 4 ankyrin-like repeats, which associates with the cytoplasmic domain of beta integrins and acts as a proximal receptor kinase regulating integrin-mediated signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [cite web | title = Entrez Gene: ILK integrin-linked kinase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3611| accessdate = ]

In 2008, ILK was found to localize to the centrosome and regulate mitotic spindle organization. [cite web | title = Fielding A, Dobreva I, "et al." (2008). "Integrin-linked kinase localizes to the centrosome and regulates mitotic spindle organization.". "J. Cell Biol." 180(4):681-9.| url = http://www.ncbi.nlm.nih.gov/pubmed/18283114| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Dedhar S |title=Cell-substrate interactions and signaling through ILK. |journal=Curr. Opin. Cell Biol. |volume=12 |issue= 2 |pages= 250–6 |year= 2000 |pmid= 10712922 |doi=
*cite journal | author=Persad S, Dedhar S |title=The role of integrin-linked kinase (ILK) in cancer progression. |journal=Cancer Metastasis Rev. |volume=22 |issue= 4 |pages= 375–84 |year= 2004 |pmid= 12884912 |doi=
*cite journal | author=Srivastava D, Yu S |title=Stretching to meet needs: integrin-linked kinase and the cardiac pump. |journal=Genes Dev. |volume=20 |issue= 17 |pages= 2327–31 |year= 2006 |pmid= 16951248 |doi= 10.1101/gad.1472506
*cite journal | author=Hannigan GE, Leung-Hagesteijn C, Fitz-Gibbon L, "et al." |title=Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase. |journal=Nature |volume=379 |issue= 6560 |pages= 91–6 |year= 1996 |pmid= 8538749 |doi= 10.1038/379091a0
*cite journal | author=Hannigan GE, Bayani J, Weksberg R, "et al." |title=Mapping of the gene encoding the integrin-linked kinase, ILK, to human chromosome 11p15.5-p15.4. |journal=Genomics |volume=42 |issue= 1 |pages= 177–9 |year= 1997 |pmid= 9177792 |doi= 10.1006/geno.1997.4719
*cite journal | author=Li F, Liu J, Mayne R, Wu C |title=Identification and characterization of a mouse protein kinase that is highly homologous to human integrin-linked kinase. |journal=Biochim. Biophys. Acta |volume=1358 |issue= 3 |pages= 215–20 |year= 1997 |pmid= 9366252 |doi=
*cite journal | author=Delcommenne M, Tan C, Gray V, "et al." |title=Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 19 |pages= 11211–6 |year= 1998 |pmid= 9736715 |doi=
*cite journal | author=Chung DH, Lee JI, Kook MC, "et al." |title=ILK (beta1-integrin-linked protein kinase): a novel immunohistochemical marker for Ewing's sarcoma and primitive neuroectodermal tumour. |journal=Virchows Arch. |volume=433 |issue= 2 |pages= 113–7 |year= 1998 |pmid= 9737788 |doi=
*cite journal | author=Tu Y, Li F, Goicoechea S, Wu C |title=The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cells. |journal=Mol. Cell. Biol. |volume=19 |issue= 3 |pages= 2425–34 |year= 1999 |pmid= 10022929 |doi=
*cite journal | author=Feng J, Ito M, Ichikawa K, "et al." |title=Inhibitory phosphorylation site for Rho-associated kinase on smooth muscle myosin phosphatase. |journal=J. Biol. Chem. |volume=274 |issue= 52 |pages= 37385–90 |year= 2000 |pmid= 10601309 |doi=
*cite journal | author=Janji B, Melchior C, Vallar L, Kieffer N |title=Cloning of an isoform of integrin-linked kinase (ILK) that is upregulated in HT-144 melanoma cells following TGF-beta1 stimulation. |journal=Oncogene |volume=19 |issue= 27 |pages= 3069–77 |year= 2000 |pmid= 10871859 |doi= 10.1038/sj.onc.1203640
*cite journal | author=Velyvis A, Yang Y, Wu C, Qin J |title=Solution structure of the focal adhesion adaptor PINCH LIM1 domain and characterization of its interaction with the integrin-linked kinase ankyrin repeat domain. |journal=J. Biol. Chem. |volume=276 |issue= 7 |pages= 4932–9 |year= 2001 |pmid= 11078733 |doi= 10.1074/jbc.M007632200
*cite journal | author=Matsumoto M, Ogawa W, Hino Y, "et al." |title=Inhibition of insulin-induced activation of Akt by a kinase-deficient mutant of the epsilon isozyme of protein kinase C. |journal=J. Biol. Chem. |volume=276 |issue= 17 |pages= 14400–6 |year= 2001 |pmid= 11278835 |doi= 10.1074/jbc.M011093200
*cite journal | author=Nikolopoulos SN, Turner CE |title=Integrin-linked kinase (ILK) binding to paxillin LD1 motif regulates ILK localization to focal adhesions. |journal=J. Biol. Chem. |volume=276 |issue= 26 |pages= 23499–505 |year= 2001 |pmid= 11304546 |doi= 10.1074/jbc.M102163200
*cite journal | author=Persad S, Attwell S, Gray V, "et al." |title=Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343. |journal=J. Biol. Chem. |volume=276 |issue= 29 |pages= 27462–9 |year= 2001 |pmid= 11313365 |doi= 10.1074/jbc.M102940200
*cite journal | author=Tu Y, Huang Y, Zhang Y, "et al." |title=A new focal adhesion protein that interacts with integrin-linked kinase and regulates cell adhesion and spreading. |journal=J. Cell Biol. |volume=153 |issue= 3 |pages= 585–98 |year= 2001 |pmid= 11331308 |doi=
*cite journal | author=Leung-Hagesteijn C, Mahendra A, Naruszewicz I, Hannigan GE |title=Modulation of integrin signal transduction by ILKAP, a protein phosphatase 2C associating with the integrin-linked kinase, ILK1. |journal=EMBO J. |volume=20 |issue= 9 |pages= 2160–70 |year= 2001 |pmid= 11331582 |doi= 10.1093/emboj/20.9.2160
*cite journal | author=Yamaji S, Suzuki A, Sugiyama Y, "et al." |title=A novel integrin-linked kinase-binding protein, affixin, is involved in the early stage of cell-substrate interaction. |journal=J. Cell Biol. |volume=153 |issue= 6 |pages= 1251–64 |year= 2001 |pmid= 11402068 |doi=
*cite journal | author=Chen R, Kim O, Yang J, "et al." |title=Regulation of Akt/PKB activation by tyrosine phosphorylation. |journal=J. Biol. Chem. |volume=276 |issue= 34 |pages= 31858–62 |year= 2001 |pmid= 11445557 |doi= 10.1074/jbc.C100271200
*cite journal | author=Fielding A, Dobreva I, McDonald PC, "et al." |title=Integrin-linked kinase localizes to the centrosome and regulates mitotic spindle organization. |journal=J. Cell Biol. |volume=180 |issue= 4 |pages= 681–9 |year= 2008 |pmid= 18283114 |doi= 10.1083/jcb.200710074

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