Monoclonal

Monoclonal

Monoclonal cells are defined as a group of cells produced from a single ancestral cell by repeated cellular replication. Thus they can be said to form a single "clone".[1] The process of replication can occur in vivo, or may be stimulated in vitro for laboratory manipulations. The use of the term typically implies that there is some method to distinguish between the cells of the original population from which the single ancestral cell is derived, such as a random genetic alteration, which is inherited by the progeny.

The most common usages of this term are:

  • Monoclonal antibodies: A single hybridoma cell, which by chance includes the appropriate V(D)J recombination to produce the desired antibody, is cloned to produce a large population of identical cells. In informal laboratory jargon the monoclonal antibodies isolated from cell culture supernatants of these hybridoma clones (hybridoma "lines") are simply called "monoclonals".
  • Monoclonal neoplasms (tumors): A single aberrant cell which has undergone an oncogenic event reproduces itself into a large cancerous mass.

References


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Look at other dictionaries:

  • MONOCLONAL — Un produit issu d’un clone cellulaire a été synthétisé par une population de cellules absolument identiques, spécialement du point de vue de leur patrimoine génétique. Ce produit ne peut donc être constitué que de molécules identiquement codées,… …   Encyclopédie Universelle

  • monoclonal — monoclonal. (De mono , clon2 y al). □ V. anticuerpo monoclonal …   Enciclopedia Universal

  • monoclonal — MONOCLONÁL, Ă adj. cu descendenţă pe cale asexuată din acelaşi strămoş. (< fr. monoclonal) Trimis de raduborza, 15.09.2007. Sursa: MDN …   Dicționar Român

  • monoclonal — (De mono , clon2 y al). ☛ V. anticuerpo monoclonal …   Diccionario de la lengua española

  • monoclonal — Relativo, perteneciente o que designa un grupo de células u organismos idénticos derivados de una única célula. Diccionario Mosby Medicina, Enfermería y Ciencias de la Salud, Ediciones Hancourt, S.A. 1999 …   Diccionario médico

  • monoclonal — [män΄ōklōn′əl, män΄əklōn′əl] adj. [ MONO + CLONAL] of cells derived or cloned from one cell …   English World dictionary

  • Monoclonal — Pertaining to a single clone of cells, a single cell and the progeny of that cell. As opposed to polyclonal. A monoclonal tumor is one that is derived from a single cell and the progeny of that cell. Monoclonal antibodies are produced by a single …   Medical dictionary

  • monoclonal — adjective Date: 1914 produced by, being, or composed of cells derived from a single cell < monoclonal antibodies > < a monoclonal tumor > • monoclonal noun …   New Collegiate Dictionary

  • monoclonal — /mon euh klohn l/, Biol. adj. 1. pertaining to cells or cell products derived from a single clone. n. 2. a monoclonal antibody or other monoclonal product. [1910 15; MONO + CLONE + AL1] * * * …   Universalium

  • monoclonal — mon•o•clo•nal [[t]ˌmɒn əˈkloʊn l[/t]] adj. 1) mcr lab pertaining to cells or cell products derived from a single biological clone 2) bai (mcr imv) a monoclonal antibody or other monoclonal product • Etymology: 1910–15 …   From formal English to slang

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