Type-II collagen
collagen, type II, alpha 1 (primary osteoarthritis, spondyloepiphyseal dysplasia, congenital)
Identifiers
Symbol COL2A1
Alt. symbols SEDC
Entrez 1280
HUGO 2200
OMIM 120140
RefSeq NM_001844
UniProt P02458
Other data
Locus Chr. 12 q13.11-q13.2

Type-II collagen is the basis for articular cartilage and hyaline cartilage.

It makes up 50% of all protein in cartilage and 85-90% of collagen of articular cartilage.

Type II collagen does form fibrils. This fibrillar network of collagen allows cartilage to entrap the proteoglycan aggregate as well as provide tensile strength to the tissue.

See also

External links

v · Protein: scleroproteins
Extracellular matrix
Fibril forming
type I (COL1A1, COL1A2) · type II (COL2A1) · type III · type V (COL5A1, COL5A2, COL5A3) · COL24A1 · COL26A1
Other

FACIT: type IX (COL9A1, COL9A2, COL9A3) · type XII (COL12A1) · COL14A1 · COL16A1 · COL19A1 · COL20A1 · COL21A1 · COL22A1

basement membrane: type IV (COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6)

multiplexin: COL15A1 · type XVIII (COL18A1, Endostatin)

transmembrane: COL13A1 · COL17A1 · COL23A1 · COL25A1

other: type VI (COL6A1, COL6A2, COL6A3) · type VII (COL7A1) · type VIII (COL8A1, COL8A2) · type X (COL10A1) · type XI (COL11A1, COL11A2) · COL27A1 · COL28A1 · COL29A1
alpha (LAMA1, LAMA2, LAMA3, LAMA4, LAMA5) · beta (LAMB1, LAMB2, LAMB3, LAMB4) · gamma (LAMC1, LAMC2, LAMC3)
Other
ALCAM · Elastin (Tropoelastin) · Vitronectin · FRAS1 · FREM2 · Decorin · FAM20C · ECM1 · Matrix gla protein · Tectorin (TECTA, TECTB)
Other
see also diseases
B proteins: BY STRUCTURE: membrane, globular (en, ca, an), fibrous

Wikimedia Foundation. 2010.

Look at other dictionaries:

  • Type-I collagen — collagen, type I, alpha 1 Identifiers Symbol COL1A1 Entrez 1277 HUGO …   Wikipedia

  • Type-IV collagen — is a type of collagen found primarily in the basal lamina. The type IV collagen C4 domain at the C terminus is not removed in post translational processing, and the fibers link head to head, rather than in parallel. Also, type IV lacks the… …   Wikipedia

  • Type-III collagen — Collagen, type III, alpha 1 (Ehlers Danlos syndrome type IV, autosomal dominant), also known as COL3A1, is a human gene. PBB Summary section title = summary text = This gene encodes a fibrillar collagen that is found in extensible connective… …   Wikipedia

  • Type XXVII collagen — is the protein predicted to be encoded by COL27A1. It was first described by Dr. James M. Pace and his colleagues at the University of Washington. It is related to the fibrillar collagens: type II, type XI, and type XXIV. Current research… …   Wikipedia

  • Collagen, type II, alpha 1 — (primary osteoarthritis, spondyloepiphyseal dysplasia, congenital) Identifiers Symbol COL2A1 Alt. symbols SEDC Entrez …   Wikipedia

  • Fibronectin type II domain — Pfam box Symbol = fn2 Name = width =250 caption =Collagen binding type II domain of seminal plasma protein PDC 109 Pfam= PF00040 InterPro= IPR000562 SMART= PROSITE = PDOC00022 SCOP = 1pdc TCDB = OPM family= 123 OPM protein= 1h8p… …   Wikipedia

  • Collagen, type X, alpha 1 — PDB rendering based on 1gr3 …   Wikipedia

  • Collagen, type IX, alpha 1 — PDB rendering based on 2uur …   Wikipedia

  • Type IV hypersensitivity — Classification and external resources MeSH D006968 Type IV hypersensitivity is often called delayed type hypersensitivity as the reaction takes two to three days to develop. Unlike the other types, it is not antibody mediated but rather is a type …   Wikipedia

  • Collagen, type I, alpha 1 — PDB rendering based on 1y0f …   Wikipedia

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”