LFA-1

LFA-1

LFA-1 stands for Lymphocyte function-associated antigen-1.

LFA-1 is found on all T-cells and also on B-cells, macrophages and neutrophils and is involved in recruitment to the site of infection. It binds to ICAM-1 on antigen-presenting cells and functions as an adhesion molecule, it is the first to bind T-cells to antigen-presenting cells and initially binds weakly. A signal from the T-cell receptor changes the conformation and prolongs the cell contact, allowing the T-cell to proliferate.

LFA-1 is part of the family of leukocyte integrins which are recognised by their common β-chains (CD18). LFA-1 also has a distinct α-chain (CD11a).

ee also

* Leukocyte adhesion deficiency

Further reading

* Janeway, Travers, Walport, Shlomchik, Immunobiology 6th ed. (2005) Garland Science:NY

External links

*
*cite journal |author=Davignon D, Martz E, Reynolds T, Kürzinger K, Springer TA |title=Lymphocyte function-associated antigen 1 (LFA-1): a surface antigen distinct from Lyt-2,3 that participates in T lymphocyte-mediated killing |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=78 |issue=7 |pages=4535–9 |year=1981 |pmid=7027264 |doi=


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