Aniracetam

Aniracetam

Systematic (IUPAC) name
1-[(4-methoxybenzoyl)]- 2-pyrrolidinone
Clinical data
Trade names	Ampamet, Memodrin, Pergamid
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	Unscheduled
Routes	Oral
Pharmacokinetic data
Half-life	1-2.5 hours
Identifiers
CAS number	72432-10-1 Y
ATC code	N06BX11
PubChem	CID 2196
DrugBank	DB04599
ChemSpider	2111 Y
UNII	5L16LKN964 Y
KEGG	D01883 Y
ChEBI	CHEBI:47943 Y
ChEMBL	CHEMBL36994 Y
Chemical data
Formula	C12H13NO3
Mol. mass	219.237 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C12H13NO3/c1-16-10-6-4-9(5-7-10)12(15)13-8-2-3-11(13)14/h4-7H,2-3,8H2,1H3 Y Key:ZXNRTKGTQJPIJK-UHFFFAOYSA-N Y
Y(what is this?)  (verify)

Aniracetam (Draganon, Sarpul, Ampamet, Memodrin) is an ampakine and nootropic of the racetam chemical class purported to be considerably more potent than piracetam. It is lipid-soluble and has possible cognition-enhancing effects. It has been tested in animals extensively, Alzheimer's patients, and temporarily-impaired healthy subjects. It has shown potential as an anxiolytic in three clinical animal models. It is sold in Europe as a prescription drug.

Pharmacology

After a confirmed test of the anxiolytic efficacy in a mouse model, haloperidol, mecamylamine, and ketanserin were applied to determine the pathways aniracetam depends on to exert its anti-anxiety effects. Haloperidol completely reversed the anxiolytic effects, and mecamylamine and ketanserin nearly completely reversed the effects. This shows that aniracetam's anxiolytic mechanism is facilitated by D₂/D₃, nACh, and 5-HT_2A receptors.^[1]

Aniracetam has also been shown to selectively modulate the AMPA receptor^[2] and was used as the parent compound to derive a class of drugs known as the ampakines that are being investigated as nootropics and neuroprotective drugs for the treatment of Alzheimer's disease and other neurodegenerative conditions.1

Despite the fat solubility of aniracetam, its half-life is much shorter than that of common racetam analogs such as piracetam.^{[citation needed]}

Commonly used doses are 750-3,000 mg daily usually taken in 2-3 doses.

Side effects can include nausea and headache.^{[citation needed]}

See also

• Ampakine
• Racetam
• Nootropic

References

1. ^ Nakamura K; Kurasawa M (May 2001). "Anxiolytic effects of aniracetam in three different mouse models of anxiety and the underlying mechanism". Eur J Pharmacol. (Kanagawa, Japan). 420 (1): 33–43. doi:10.1016/S0014-2999(01)01005-6. PMID 11412837. 
2. ^ Ito et al. J. Physiol. 1990; 424: 533-543.

External links

• The Cognitive Enhancement Research Institute

This drug article relating to the nervous system is a stub. You can help Wikipedia by expanding it.v · Categories: Pyrrolidines Nootropics Racetams Ampakines AMPA receptor modulators Nervous system drug stubs Wikimedia Foundation. 2010. Игры ⚽ Нужен реферат? Motorcycle Hall of Fame Kölner Haie Look at other dictionaries: Aniracetam — Strukturformel Allgemeines Freiname Aniracetam …   Deutsch Wikipedia aniracetam — noun A nootropic ampakine compound of the racetam family purported to be considerably more potent than piracetam …   Wiktionary Nootropic — Nootropics (  /noʊ.ɵ …   Wikipedia Ampakine — Ampakines are a new class of compounds known to enhance attention span and alertness, and facilitate learning and memory. The ampakines take their name from the glutamatergic AMPA receptor with which they strongly interact. The AMPA receptor, in… …   Wikipedia Ampakine — AMPA Les ampakines sont une classe de composés connus pour augmenter la capacité d attention et de vigilance et pour faciliter l apprentissage et la mémoire. Les ampakines tirent leur nom des récepteurs AMPA glutamatergiques avec lesquels elles… …   Wikipédia en Français IDRA-21 — drugbox IUPAC name = 7 chloro 3 methyl 3,4 dihydro 2H benzo [e] [1,2,4] thiadiazine 1,1 dioxide width = 200 CAS number = 163936 78 5 synonyms = IDRA 21 ATC prefix = ATC suffix = PubChem = 3688 DrugBank = C = 8 | H = 9 | Cl = 1 | N = 2 | O = 2 | S …   Wikipedia PEPA (drug) — For the process algebra, see PEPA. PEPA (drug) Systematic (IUPAC) name 2 [2,6 difluoro 4 ({2 [(phenylsulfonyl)amino]ethyl}thio)phenoxy]acetamide Clinical data …   Wikipedia Nootrópicos — Nootrópico, también conocidos drogas inteligentes, estimulantes de la memoria, y potenciadores cognitivos, son las sustancias como drogas, suplementos, nutracéuticos y alimentos funcionales que elevan las funciones mentales humanas (las funciones …   Wikipedia Español Nicoracetam — Systematic (IUPAC) name 1 (6 methoxynicotinoyl)pyrrolidin 2 one Clinical data Pregnancy cat.  ? …   Wikipedia Piracetam — Systematic (IUPAC) name 2 oxo 1 pyrrolidineacetamide Clinical data …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”