CXCL11

CXCL11

Chemokine (C-X-C motif) ligand 11 (CXCL11)cite web | title = Entrez Gene: CXCL11 chemokine (C-X-C motif) ligand 11| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6373| accessdate = ] is a small cytokine belonging to the CXC chemokine family that is also called "Interferon-inducible T-cell alpha chemoattractant" (I-TAC) and "Interferon-gamma-inducible protein 9" (IP-9). It is highly expressed in peripheral blood leukocytes, pancreas and liver, with moderate levels in thymus, spleen and lung and low expression levels were in small intestine, placenta and prostate.cite journal | author = Cole KE, Strick CA, Paradis TJ, Ogborne KT, Loetscher M, Gladue RP, Lin W, Boyd JG, Moser B, Wood DE, Sahagan BG, Neote K | title = Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3 | journal = J. Exp. Med. | volume = 187 | issue = 12 | pages = 2009–21 | year = 1998 | pmid = 9625760 | doi = 10.1084/jem.187.12.2009 ] Gene expression of CXCL11 is strongly induced by IFN-γ and IFN-β, and weakly induced by IFN-α.cite journal | author = Rani MR, Foster GR, Leung S, Leaman D, Stark GR, Ransohoff RM | title = Characterization of beta-R1, a gene that is selectively induced by interferon beta (IFN-beta) compared with IFN-alpha | journal = J. Biol. Chem. | volume = 271 | issue = 37 | pages = 22878–84 | year = 1996 | pmid = 8798467 | doi = 10.1074/jbc.271.37.22878 ] This chemokine elicits its effects on its target cells by interacting with the cell surface chemokine receptor CXCR3, with a higher affinity than do the other ligands for this receptor, CXCL9 and CXCL10.cite journal | author = Tensen CP, Flier J, Van Der Raaij-Helmer EM, Sampat-Sardjoepersad S, Van Der Schors RC, Leurs R, Scheper RJ, Boorsma DM, Willemze R | title = Human IP-9: A keratinocyte-derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3) | journal = J. Invest. Dermatol. | volume = 112 | issue = 5 | pages = 716–22 | year = 1999 | pmid = 10233762 | doi = 10.1046/j.1523-1747.1999.00581.x ] CXCL11 is chemotactic for activated T cells. Its gene is located on human chromosome 4 along with many other members of the CXC chemokine family.cite journal | author = Erdel M, Laich A, Utermann G, Werner ER, Werner-Felmayer G | title = The human gene encoding SCYB9B, a putative novel CXC chemokine, maps to human chromosome 4q21 like the closely related genes for MIG (SCYB9) and INP10 (SCYB10) | journal = Cytogenet. Cell Genet. | volume = 81 | issue = 3-4 | pages = 271–2 | year = 1998 | pmid = 9730616 | doi = 10.1159/000015043 ] cite journal | author = O'Donovan N, Galvin M, Morgan JG | title = Physical mapping of the CXC chemokine locus on human chromosome 4 | journal = Cytogenet. Cell Genet. | volume = 84 | issue = 1-2 | pages = 39–42 | year = 1999 | pmid = 10343098 | doi = 10.1159/000015209 ]

References

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Rani MR, Foster GR, Leung S, "et al." |title=Characterization of beta-R1, a gene that is selectively induced by interferon beta (IFN-beta) compared with IFN-alpha. |journal=J. Biol. Chem. |volume=271 |issue= 37 |pages= 22878–84 |year= 1996 |pmid= 8798467 |doi=10.1074/jbc.271.37.22878
*cite journal | author=Jacobs KA, Collins-Racie LA, Colbert M, "et al." |title=A genetic selection for isolating cDNAs encoding secreted proteins. |journal=Gene |volume=198 |issue= 1-2 |pages= 289–96 |year= 1997 |pmid= 9370294 |doi=10.1016/S0378-1119(97)00330-2
*cite journal | author=Cole KE, Strick CA, Paradis TJ, "et al." |title=Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3. |journal=J. Exp. Med. |volume=187 |issue= 12 |pages= 2009–21 |year= 1998 |pmid= 9625760 |doi=10.1084/jem.187.12.2009
*cite journal | author=Erdel M, Laich A, Utermann G, "et al." |title=The human gene encoding SCYB9B, a putative novel CXC chemokine, maps to human chromosome 4q21 like the closely related genes for MIG (SCYB9) and INP10 (SCYB10). |journal=Cytogenet. Cell Genet. |volume=81 |issue= 3-4 |pages= 271–2 |year= 1998 |pmid= 9730616 |doi=10.1159/000015043
*cite journal | author=Luo Y, Kim R, Gabuzda D, "et al." |title=The CXC-chemokine, H174: expression in the central nervous system. |journal=J. Neurovirol. |volume=4 |issue= 6 |pages= 575–85 |year= 1999 |pmid= 10065899 |doi=10.3109/13550289809114224
*cite journal | author=Tensen CP, Flier J, Van Der Raaij-Helmer EM, "et al." |title=Human IP-9: A keratinocyte-derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3). |journal=J. Invest. Dermatol. |volume=112 |issue= 5 |pages= 716–22 |year= 1999 |pmid= 10233762 |doi= 10.1046/j.1523-1747.1999.00581.x
*cite journal | author=Laich A, Meyer M, Werner ER, Werner-Felmayer G |title=Structure and expression of the human small cytokine B subfamily member 11 (SCYB11/formerly SCYB9B, alias I-TAC) gene cloned from IFN-gamma-treated human monocytes (THP-1). |journal=J. Interferon Cytokine Res. |volume=19 |issue= 5 |pages= 505–13 |year= 1999 |pmid= 10386863 |doi= 10.1089/107999099313956
*cite journal | author=Tensen CP, Flier J, Rampersad SS, "et al." |title=Genomic organization, sequence and transcriptional regulation of the human CXCL 11(1) gene. |journal=Biochim. Biophys. Acta |volume=1446 |issue= 1-2 |pages= 167–72 |year= 1999 |pmid= 10395932 |doi=
*cite journal | author=Loetscher P, Pellegrino A, Gong JH, "et al." |title=The ligands of CXC chemokine receptor 3, I-TAC, Mig, and IP10, are natural antagonists for CCR3. |journal=J. Biol. Chem. |volume=276 |issue= 5 |pages= 2986–91 |year= 2001 |pmid= 11110785 |doi= 10.1074/jbc.M005652200
*cite journal | author=Lambeir AM, Proost P, Durinx C, "et al." |title=Kinetic investigation of chemokine truncation by CD26/dipeptidyl peptidase IV reveals a striking selectivity within the chemokine family. |journal=J. Biol. Chem. |volume=276 |issue= 32 |pages= 29839–45 |year= 2001 |pmid= 11390394 |doi= 10.1074/jbc.M103106200
*cite journal | author=Hensbergen PJ, van der Raaij-Helmer EM, Dijkman R, "et al." |title=Processing of natural and recombinant CXCR3-targeting chemokines and implications for biological activity. |journal=Eur. J. Biochem. |volume=268 |issue= 18 |pages= 4992–9 |year= 2001 |pmid= 11559369 |doi=10.1046/j.0014-2956.2001.02433.x
*cite journal | author=Mohan K, Ding Z, Hanly J, Issekutz TB |title=IFN-gamma-inducible T cell alpha chemoattractant is a potent stimulator of normal human blood T lymphocyte transendothelial migration: differential regulation by IFN-gamma and TNF-alpha. |journal=J. Immunol. |volume=168 |issue= 12 |pages= 6420–8 |year= 2002 |pmid= 12055261 |doi=
*cite journal | author=Basu S, Schaefer TM, Ghosh M, "et al." |title=Molecular cloning and sequencing of 25 different rhesus macaque chemokine cDNAs reveals evolutionary conservation among C, CC, CXC, AND CX3C families of chemokines. |journal=Cytokine |volume=18 |issue= 3 |pages= 140–8 |year= 2003 |pmid= 12126650 |doi=10.1006/cyto.2002.0875
*cite journal | author=Salmaggi A, Gelati M, Dufour A, "et al." |title=Expression and modulation of IFN-gamma-inducible chemokines (IP-10, Mig, and I-TAC) in human brain endothelium and astrocytes: possible relevance for the immune invasion of the central nervous system and the pathogenesis of multiple sclerosis. |journal=J. Interferon Cytokine Res. |volume=22 |issue= 6 |pages= 631–40 |year= 2003 |pmid= 12162873 |doi= 10.1089/10799900260100114
*cite journal | author=Rani MR, Hibbert L, Sizemore N, "et al." |title=Requirement of phosphoinositide 3-kinase and Akt for interferon-beta-mediated induction of the beta-R1 (SCYB11) gene. |journal=J. Biol. Chem. |volume=277 |issue= 41 |pages= 38456–61 |year= 2002 |pmid= 12169689 |doi= 10.1074/jbc.M203204200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Kao J, Kobashigawa J, Fishbein MC, "et al." |title=Elevated serum levels of the CXCR3 chemokine ITAC are associated with the development of transplant coronary artery disease. |journal=Circulation |volume=107 |issue= 15 |pages= 1958–61 |year= 2003 |pmid= 12695288 |doi= 10.1161/01.CIR.0000069270.16498.75
*cite journal | author=Satish L, Yager D, Wells A |title=Glu-Leu-Arg-negative CXC chemokine interferon gamma inducible protein-9 as a mediator of epidermal-dermal communication during wound repair. |journal=J. Invest. Dermatol. |volume=120 |issue= 6 |pages= 1110–7 |year= 2003 |pmid= 12787142 |doi= 10.1046/j.1523-1747.2003.12230.x
*cite journal | author=Klunker S, Trautmann A, Akdis M, "et al." |title=A second step of chemotaxis after transendothelial migration: keratinocytes undergoing apoptosis release IFN-gamma-inducible protein 10, monokine induced by IFN-gamma, and IFN-gamma-inducible alpha-chemoattractant for T cell chemotaxis toward epidermis in atopic dermatitis. |journal=J. Immunol. |volume=171 |issue= 2 |pages= 1078–84 |year= 2003 |pmid= 12847282 |doi=
*cite journal | author=Xanthou G, Duchesnes CE, Williams TJ, Pease JE |title=CCR3 functional responses are regulated by both CXCR3 and its ligands CXCL9, CXCL10 and CXCL11. |journal=Eur. J. Immunol. |volume=33 |issue= 8 |pages= 2241–50 |year= 2003 |pmid= 12884299 |doi= 10.1002/eji.200323787

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