Heterocysts are specialized nitrogen-fixing cells formed by some filamentous cyanobacteria, such as "Nostoc punctiforme", "Cylindrospermum stagnale" and "Anabaena sperica", during nitrogen starvation. They fix nitrogen from dinitrogen (N2) in the air using the enzyme nitrogenase, in order to provide the cells in the filament with nitrogen for biosynthesis. Nitrogenase is inactivated by oxygen, so the heterocyst must create a microanaerobic environment. The heterocysts' unique structure and physiology requires a global change in gene expression. For example, heterocysts:

* produce three additional cell walls, including one of glycolipid that forms a hydrophobic barrier to oxygen
* produce nitrogenase and other proteins involved in nitrogen fixation
* degrade photosystem II, which produces oxygen
* up-regulate glycolytic enzymes
* produce proteins that scavenge any remaining oxygen

Cyanobacteria usually obtain a fixed carbon (carbohydrate) by photosynthesis. The lack of photosystem II prevents heterocysts from photosynthesising, so the vegetative cells provide them with carbohydrates, which is thought to be sucrose. The fixed carbon and nitrogen sources are exchanged though channels between the cells in the filament. Heterocysts maintain photosystem I, allowing them to generate ATP by cyclic photophosphorylation.

Single heterocysts develop about every 9-15 cells, producing a one-dimensional pattern along the filament. The interval between heterocysts remains approximately constant even though the cells in the filament are dividing. The bacterial filament can be seen as a multicellular organism with two distinct yet interdependent cell types. Such behaviour is highly unusual in prokaryotes and may have been the first example of multicellular patterning in evolution. Once a heterocyst has formed, it cannot revert to a vegetative cell, so this differentiation can be seen as a form of apoptosis. Certain heterocyst-forming bacteria can differentiate into spore-like cells called akinetes or motile cells called hormogonia, making them the most phenotyptically versatile of all prokaryotes.

The mechanism of controlling heterocysts is thought to involve the diffusion of an inhibitor of differentiation called patS. Heterocyst formation is inhibited in the presence of a fixed nitrogen source, such as ammonium or nitrate. Heterocyst maintenance is dependent on an enzyme called hetN. The bacteria may also enter a symbiotic relationship with certain plants. In such a relationship, the bacteria do not respond to the availability of nitrogen, but to signals produced by the plant. Up to 60% of the cells can become heterocysts, providing fixed nitrogen to the plant in return for fixed carbon.

The cyanobacteria that form heterocysts are divided into the orders Nostocales and Stigonematales, which form simple and branching filaments respectively. Together they form a monophyletic group, with very low genetic variability.

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  • Heterocyst — Het er*o*cyst, n. [Hetero + cyst.] (Bot.) A cell larger than the others, and of different appearance, occurring in certain alg[ae] related to nostoc. [1913 Webster] …   The Collaborative International Dictionary of English

  • heterocyst — noun Date: 1872 a large transparent thick walled cell that is found in the filaments of some cyanobacteria and is the site of nitrogen fixation • heterocystous adjective …   New Collegiate Dictionary

  • heterocyst — Specialized cell type found at regular intervals along the filaments of certain Cyanobacteria; site of nitrogen fixation …   Dictionary of molecular biology

  • heterocyst — /het euhr euh sist /, n. Bacteriol. one of the enlarged nitrogen fixing cells occurring along the filaments in some blue green algae. [1870 75; HETERO + CYST] * * * …   Universalium

  • heterocyst — het·ero·cyst …   English syllables

  • heterocyst — het•er•o•cyst [[t]ˈhɛt ər əˌsɪst[/t]] n. mcr one of the enlarged nitrogen fixing cells along the filaments in some blue green algae • Etymology: 1870–75 …   From formal English to slang

  • heterocyst — ˈhed.ərəˌsist noun Etymology: International Scientific Vocabulary heter + cyst : one of the large transparent thick walled cells resembling spores occurring at intervals along the filament in certain filamentous blue green algae …   Useful english dictionary

  • heterocystous — adjective see heterocyst …   New Collegiate Dictionary

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  • Cyanobacteria — Temporal range: 3500–0 Ma Had n Archean …   Wikipedia

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