Neuronal calcium sensor

Neuronal Calcium Sensor is a large family of proteins which work as calcium dependent molecular switches and includes members like Frequenin (NCS1), recoverin, GCAP, neurocalcin, visinin etc ^[1]. All the members carry 4 EF hand motifs (out of which only 2 or 3 bind calcium) and an N-myristoyl group.^[2]

Members of NCS family

• Highly evolutionarily conserved ^[3]

• NCS1 (Frequenin)
• VILIP-1 (Visinin-like-protein-1)
• HPCAL4 (Visinin-like-protein-2)
• HPCAL1 (Visinin-like-protein-3)
• hippocalcin
• neurocalcin
• recoverin
• Guanylate cyclase activator proteins (GCAPs)
• Potassium Channel interacting proteins (KChIPs 1-4), including:

KCNIP1, KCNIP2, Calsenilin or DREAM/KChIP-3/KCNIP3 (downstream regulatory element antagonist modulator/potassium channel interacting protein), KCNIP4

References

1. ^ Burgoyne RD (2007). "Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling". Nat. Rev. Neurosci. 8 (3): 182–193. doi:10.1038/nrn2093. PMC 1887812. PMID 17311005. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1887812. 
2. ^ Burgoyne RD, O'Callaghan DW, Hasdemir B, Haynes LP, Tepikin AV (2004). "Neuronal Ca2+-sensor proteins: multitalented regulators of neuronal function". Trends Neurosci. 27 (4): 203–9. doi:10.1016/j.tins.2004.01.010. PMID 15046879. 
3. ^ Weiss JL, Hui H, Burgoyne RD (2010). "Neuronal calcium sensor-1 regulation of calcium channels, secretion, and neuronal outgrowth.". Cell Mol Neurobiol. 30 (8): 1283–92. PMID 21104311. 

External links

• MeSH Neuronal+Calcium-Sensor+Proteins
• NCS proteins

This protein-related article is a stub. You can help Wikipedia by expanding it.v · Categories: Proteins Protein stubs Wikimedia Foundation. 2010. Игры ⚽ Поможем сделать НИР Hemimetric space Northfield Square Mall Look at other dictionaries: Neuronal calcium sensor-1 — PDB rendering based on 1g8i …   Wikipedia VSNL1 — Visinin like 1, also known as VSNL1, is a human gene.cite web | title = Entrez Gene: VSNL1 visinin like 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=7447| accessdate = ] PBB Summary section title =… …   Wikipedia Neurocalcin — delta Identifiers Symbol NCALD Entrez …   Wikipedia HPCAL1 — Hippocalcin like 1, also known as HPCAL1, is a human gene.cite web | title = Entrez Gene: HPCAL1 hippocalcin like 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=3241| accessdate = ] PBB Summary section… …   Wikipedia PI4KB — Phosphatidylinositol 4 kinase, catalytic, beta polypeptide, also known as PIK4CB, is a human gene.cite web | title = Entrez Gene: PIK4CB phosphatidylinositol 4 kinase, catalytic, beta polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db …   Wikipedia S-100 protein — S 100/ICaBP type calcium binding domain Identifiers Symbol S 100 Pfam PF01023 InterPro …   Wikipedia PPP1R1B — Protein phosphatase 1, regulatory (inhibitor) subunit 1B Identifiers Symbols PPP1R1B; DARPP 32; DARPP32; FLJ20940 External IDs …   Wikipedia Gap-43 protein — Growth associated protein 43 Identifiers Symbols GAP43; B 50; PP46 External IDs OMIM …   Wikipedia Hippocalcin — protein Name = hippocalcin caption = width = HGNCid = 5144 Symbol = HPCA AltSymbols = EntrezGene = 3208 OMIM = 142622 RefSeq = NM 002143 UniProt = P84074 PDB = ECnumber = Chromosome = 1 Arm = p Band = 35 LocusSupplementaryData = p34.2Hippocalcin… …   Wikipedia Dopamine receptor D5 — Identifiers Symbols DRD5; DBDR; DRD1B; DRD1L2; MGC10601 External IDs …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”