Syk

Syk

Spleen tyrosine kinase, also known as SYK, is a human protein and gene.

SYK, along with Zap-70, is a member of the Syk family of tyrosine kinases. These non-receptor cytoplasmic tyrosine kinases share a characteristic dual SH2 domain separated by a linker domain.

While Syk and Zap-70 are primarily expressed in hematopoietic tissues, there is expression of Syk in a variety of tissues. Within B and T cells respectively, Syk and Zap-70 transmit signals from the B-Cell receptor and T-Cell receptor. Syk plays a similar role in transmitting signals from a variety of cell surface receptors including CD74, Fc Receptor, and integrins.

Abnormal function of Syk has been implicated in several instances of hematopoeitic malignancies including translocations involving Itk and Tel. Constitutive Syk activity can transform B cells. Several transforming viruses contain "Immunoreceptor Tyrosine Activation Motifs" (ITAMs) which lead to activation of Syk including Epstein Barr virus, bovine leukemia virus, and mouse mammary tumor virus.

The role of Syk in epithelial malignancies is controversial. Several authors have suggested that abnormal Syk function facilitates transformation in Nasopharyngeal carcinoma and head and neck cancer while other authors have suggested a tumor supressor role in breast and gastric cancer.

Further reading

PBB_Further_reading
citations =
*cite journal | author=Turner M, Schweighoffer E, Colucci F, "et al." |title=Tyrosine kinase SYK: essential functions for immunoreceptor signalling. |journal=Immunol. Today |volume=21 |issue= 3 |pages= 148–54 |year= 2000 |pmid= 10689303 |doi=
*cite journal | author=Fruman DA, Satterthwaite AB, Witte ON |title=Xid-like phenotypes: a B cell signalosome takes shape. |journal=Immunity |volume=13 |issue= 1 |pages= 1–3 |year= 2000 |pmid= 10933389 |doi=
*cite journal | author=Yanagi S, Inatome R, Takano T, Yamamura H |title=Syk expression and novel function in a wide variety of tissues. |journal=Biochem. Biophys. Res. Commun. |volume=288 |issue= 3 |pages= 495–8 |year= 2001 |pmid= 11676469 |doi= 10.1006/bbrc.2001.5788
*cite journal | author=Tohyama Y, Yamamura H |title=Complement-mediated phagocytosis--the role of Syk. |journal=IUBMB Life |volume=58 |issue= 5-6 |pages= 304–8 |year= 2006 |pmid= 16754322 |doi= 10.1080/15216540600746377
*cite journal | author=Schymeinsky J, Mócsai A, Walzog B |title=Neutrophil activation via beta2 integrins (CD11/CD18): molecular mechanisms and clinical implications. |journal=Thromb. Haemost. |volume=98 |issue= 2 |pages= 262–73 |year= 2007 |pmid= 17721605 |doi=

External links

*

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes


Wikimedia Foundation. 2010.

Игры ⚽ Нужно сделать НИР?

Look at other dictionaries:

  • syk — {{/stl 13}}{{stl 8}}rz. mnż IIa, D. u {{/stl 8}}{{stl 7}} dźwięk podobny do przeciągłej artykulacji spółgłoski {{/stl 7}}{{stl 8}}s {{/stl 8}}{{stl 7}} : {{/stl 7}}{{stl 10}}Syk żmii. Syk pary. {{/stl 10}} …   Langenscheidt Polski wyjaśnień

  • syk — obs. f. sic, sick, sike …   Useful english dictionary

  • sykþ — obs. 3 sing. pres. of see v …   Useful english dictionary

  • syk — m III, D. u, N. sykkiem; lm M. i «głos przypominający przeciągłe wymawianie spółgłoski s; syczenie» Syk parowozu. Syk płomieni. Syk węża …   Słownik języka polskiego

  • syk — sỹk adv. 1. NdŽ sykį: Gaidys pakrosnėje rėkia visa gerkle, nežinia kurį jau syk V.Krėv. Su galva dirbt ne sỹk – dešimtkart sunkiau LKT207(Graž). 2. kartu, sykiu: Šv. Jurgio diena artinosi ir syk laikas, paskirtas įnešti į banką aštuonias… …   Dictionary of the Lithuanian Language

  • syk — Tyrosine kinase (72 kD), an effector of the B cell receptor signalling pathway. Contains two tandem SH2 domains through which it interacts with ITAM motif. More widely distributed than zap70 and important in signalling in both myeloid and… …   Dictionary of molecular biology

  • SYK — Spleen Tyrosine Kinase (Medical » Laboratory) Stryker Corporation (Business » NYSE Symbols) * Stykkisholmur, Iceland (Regional » Airport Codes) * Show You Know (Internet » Chat) * SYLK spreadsheet format (Excel) (Computing » File Extensions) …   Abbreviations dictionary

  • syk — ISO 639 3 Code of Language ISO 639 2/B Code : ISO 639 2/T Code : ISO 639 1 Code : Scope : Individual Language Type : Living Language Name : Sukur …   Names of Languages ISO 639-3

  • SYK — So You Know …   Glossary of chat acronyms & text shorthand

  • SYK — abbr. Spleen Tyrosine Kinase …   Dictionary of abbreviations

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”