Hassall's corpuscles

Hassall's corpuscles
Micrograph of a thymic corpuscle. H&E stain.
Gray's	subject #274 1274

Hassall's corpuscles (or thymic corpuscles) are structures found in the medulla of the human thymus, formed from eosinophilic dead type VI epithelial reticular cells arranged concentrically. They are named for Arthur Hill Hassall, who discovered them in 1849.

The function of Hassall's corpuscles is currently unclear, and the absence of this structure in the murine thymus has restricted mechanistic dissection. It is known that Hassall's corpuscles are a potent source of the cytokine TSLP. In vitro, TSLP directs the maturation of dendritic cells, and increases the ability of dendritic cells to convert naive thymocytes to a Foxp3+ regulatory T cell lineage.^[1][2] It is unknown if this is the physiological function of Hassall's corpuscles in vivo.

Hassall's corpuscles vary in size with diameters from 20 to more than 100μm, and tend to grow larger with age.^[3]

References

1. ^ * Watanabe N, Wang Y, Lee H, Ito T, Wang Y, Cao W, Liu Y (2005). "Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus.". Nature 436 (7054): 1181–5. doi:10.1038/nature03886. PMID 16121185. 
2. ^ "Old mystery solved, revealing origin of regulatory T cells that 'police' and protect the body"
3. ^ Geneser, Finn (1999). Histologi. Munksgaard Danmark. ISBN 8762801376. 

External links

• synd/1912 at Who Named It?
• UIUC Histology Subject 1247
• Histology at KUMC lymphoid-lymph03 "Hassall's Corpuscles"
• Histology at OU 61_05 - "Thymus"
• Histology at BU 07407loa - "Lymphoid Tissues and Organs: thymus, Hassall's corpuscles"

This anatomy article is a stub. You can help Wikipedia by expanding it.v · Categories: Histology Anatomy stubs Wikimedia Foundation. 2010. Игры ⚽ Поможем сделать НИР Diesel Park West Novokhopyorsk Look at other dictionaries: Hassall-Körperchen — in menschlichem Thymusgewebe Hassall Körperchen (lat. Corpuscula thymi) sind runde, schichtweise Zusammenballungen von mehreren Retikulumzellen in einem normalen Thymus. Sie sind besonders im Thymusmark anzutreffen. Die Retikulumzellen zeigen im… …   Deutsch Wikipedia Hassall body — Hassall corpuscles …   Medical dictionary Hassall corpuscles — spherical or ovoid bodies found in the medulla of the thymus, composed of concentric arrays of epithelial cells which contain keratohyalin and bundles of cytoplasmic filaments. Called also Hassall bodies and concentric, Leber, or thymus c s.… …   Medical dictionary Hassall corpuscles (bodies) — Has·sall corpuscles (bodies) (hasґəl) [Arthur Hill Hassall, English chemist and physician, 1817–1894] see under corpuscle …   Medical dictionary Arthur Hill Hassall — (13 December 1817, Teddington 9 April 1894, San Remo) was a British physician, chemist and microscopist who is primarily known for his work in public health and food safety.He entered medicine through apprenticeship in 1834 to his uncle Sir James …   Wikipedia concentric corpuscles — Hassall c s …   Medical dictionary Gierke corpuscles — Hassall c s …   Medical dictionary Leber corpuscles — Hassall c s …   Medical dictionary thymus corpuscles — Hassall c s …   Medical dictionary Hassallsches Körperchen — Hassall Körperchen in menschlichem Thymusgewebe Hassall Körperchen (lat. Corpuscula thymi) sind runde, schichtweise Zusammenballungen von mehreren Retikulumzellen in einem normalen Thymus. Sie sind besonders im Thymusmark anzutreffen. Die… …   Deutsch Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”