Calcium-binding protein

Calcium-binding protein

Calcium-binding proteins are proteins that participate in calcium cell signalling pathways by binding to Ca2+.

The most ubiquitous Ca2+-sensing protein, found in all eukaryotic organisms including yeasts, is calmodulin.

Intracellular storage and release of Ca2+ from the sarcoplasmic reticulum is associated with the high-capacity, low-affinity calcium-binding protein, calsequestrin. [Siegel, George (Ed.). "Basic neurochemistry : molecular, cellular and medical aspects". Lippincott Williams and Wilkins / 1999 ISBN 0-397-51820-X]

With their role in signal transduction, calcium-binding proteins contribute to all aspects of the cell's functioning, from homeostasis to learning and memory.

For example, the neuron-specific calexcitin has been found to have an excitatory effect on neurons, and interacts with proteins that control the firing state of neurons, such as the the voltage-dependent potassium channel. [cite journal |author=Nelson T, Cavallaro S, Yi C, McPhie D, Schreurs B, Gusev P, Favit A, Zohar O, Kim J, Beushausen S, Ascoli G, Olds J, Neve R, Alkon D |title=Calexcitin: a signaling protein that binds calcium and GTP, inhibits potassium channels, and enhances membrane excitability |journal=Proc Natl Acad Sci U S A |volume=93 |issue=24 |pages=13808–13 |year=1996 |pmid=8943017 |doi=10.1073/pnas.93.24.13808]

ee also

* Vitamin D-dependent calcium-binding protein
*

References

External links

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