Aspartylglucosaminidase

Aspartylglucosaminidase
Aspartylglucosaminidase

PDB rendering based on 1apy.
Identifiers
Symbols AGA; AGU; ASRG; GA
External IDs OMIM613228 MGI104873 HomoloGene13 GeneCards: AGA Gene
EC number 3.5.1.26
RNA expression pattern
PBB GE AGA 204333 s at tn.png
PBB GE AGA 204332 s at tn.png
PBB GE AGA 216064 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 175 11593
Ensembl ENSG00000038002 ENSMUSG00000031521
UniProt P20933 Q64191
RefSeq (mRNA) NM_000027.3 NM_001005847
RefSeq (protein) NP_000018.2 NP_001005847
Location (UCSC) Chr 4:
178.35 – 178.36 Mb
Chr 8:
54.6 – 54.61 Mb
PubMed search [1] [2]

N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase is an enzyme that in humans is encoded by the AGA gene.[1]

Aspartylglucosaminidase is an amidohydrolase enzyme involved in the catabolism of N-linked oligosaccharides of glycoproteins. It cleaves asparagine from N-acetylglucosamines as one of the final steps in the lysosomal breakdown of glycoproteins. The lysosomal storage disease aspartylglycosaminuria is caused by a deficiency in the AGA enzyme.[1]

References

Further reading

External links



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  • aspartylglucosaminidase — noun A human gene and amidohydrolase enzyme involved in the catabolism of N linked oligosaccharides of glycoproteins. Syn: AGA …   Wiktionary

  • aspartylglucosaminidase — as·par·tyl·glu·co·sa·min·i·dase (ə spahr″təl gloo kōs″ə minґĭ dās) a lysosomal enzyme of the hydrolase class that catalyzes the cleavage of N glycosidic linkages between N acetylglucosamine and asparagine …   Medical dictionary

  • Aspartylglucosaminuria — Infobox Disease Name = PAGENAME Caption = Aspartylglucosamine DiseasesDB = 952 ICD10 = ICD10|E|77|1|e|70 ICD9 = ICDO = OMIM = 208400 MedlinePlus = eMedicineSubj = eMedicineTopic = MeshID = Aspartylglucosaminuria (AGU), also called… …   Wikipedia

  • AGA — is a three letter acronym that may refer to: * AGA (automobile) * AGA AB, a Swedish industrial gas company * AGA cooker * Advanced Graphics Architecture, Commodore Amiga graphics chipset * Al Massira Airport, Agadir, Morocco, from its IATA… …   Wikipedia

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  • Glycoprotein — Not to be confused with peptidoglycan or proteoglycan. N linked protein glycosylation (N glycosylation of N glycans) at Asn residues (Asn x Ser/Thr motifs) in glycoproteins.[1] Glycoproteins are proteins that contain oligosaccharide chai …   Wikipedia

  • Arginase — Liver arginase ArginasePDB 1CEV. Identifiers Symbol ARG1 …   Wikipedia

  • Neuraminidase — Neuraminic acid Neuraminidase enzymes are glycoside hydrolase enzymes (EC 3.2.1.18) that cleave the glycosidic linkages of neuraminic acids. Neuraminidase enzymes are a large family, found in a range of organisms. The most commonly known… …   Wikipedia

  • Asparaginase — Systematic (IUPAC) name E. coli L asparagine amidohydrolase Clinical data Trade names Elspar …   Wikipedia

  • Oligosaccharyltransferase — or OST (EC 2.4.1.119) is a membrane protein complex that transfers a 14 sugar oligosaccharide from dolichol to nascent protein. It is a type of glycosyltransferase. The sugar Glc3Man9GlcNAc2 (where Glc=Glucose, Man=Mannose, and GlcNAc=N… …   Wikipedia

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