Genotoxicity

Genotoxicity describes a deleterious action on a cell genetic material affecting its integrity. Genotoxic substances are known to be potentially mutagenic or carcinogenic, specifically those capable of causing genetic mutation and of contributing to the development of tumors. This includes both certain chemical compounds and certain types of radiation.

Typical genotoxins like aromatic amines are believed to cause mutations because they are nucleophilic and form strong covalent bonds with DNA resulting with the formation of Aromatic Amine-DNA Adducts, preventing accurate replication.

ee also

Mutagen

References

* [http://ehp.niehs.nih.gov/docs/1996/Suppl-6/smith.html Environ Health Perspect 104(Suppl 6):1219-1225 (1996)] - The Mechanism of Benzene-induced Leukemia: A Hypothesis and Speculations on the Causes of Leukemia