BMPR1A

Protbox
Name=Bone morphogenetic protein receptor, type IA
Photo=BMPR1A.pngCaption=Ternary Complex Of Bmp-2 Bound To Bmpr-Ia-Ecd And Actrii-Ecd
HGNCid =
Symbol =
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Names=Serine/threonine-protein kinase receptor R5, SKR5, Activin receptor-like kinase 3, ALK-3, CD292 antigen
Chromosome = 10
Arm = q
Band = 22.3
LocusSupplementaryData =
Gene= HUGO code: [http://www.gene.ucl.ac.uk/nomenclature/data/get_data.php?hgnc_id=HGNC:1076 BMPR1A]
Gene_type=Protein coding
Protein_length=532
Molecular_weight=60198
Structure= [http://bip.weizmann.ac.il/oca-bin/ocashort?id=1ES7 Complex Between Bmp-2 And Two Bmp Receptor Ia Ectodomains]
Type=Receptor serine/threonine kinase
Functions=Receptor binding
Domains=TM domain S/T domain, GS domain
Motifs=SP motif
Alternative_products=
Catalytic_activity=ATP + (receptor-protein) = ADP + receptor-protein phosphate
Cofactors=Magnesium or manganese
Enzyme_regulation=
Diseases=Juvenile polyposis syndrome (JPS) OMIM|174900; Cowden disease (CD) OMIM|158350; Hereditary mixed polyposis syndrome 2 (HMPS2) OMIM|610069
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Taxa= Homo sapiens: homologs: many metazoan phyla
Cells= many; prostate. cornea, brain
Location= Plasma membrane
Mods=
Pathways=TGF beta signaling pathway ( [http://www.genome.ad.jp/dbget-bin/show_pathway?hsa04350+657 KEGG] ) Cytokine-cytokine receptor interaction ( [http://www.genome.ad.jp/dbget-bin/show_pathway?hsa04060+657 KEGG] )
Interactions=
Actions=
Agonists=BMP2, BMP6, BMP7, GDF6
Antagonists=Noggin, Chordin
EntrezGene =
OMIM =
RefSeq =
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Review= The BMPR1A receptor binds BMP2 and BMP4. BMPR1A has also been designated as CD292 (cluster of differentiation 290).

BMP's repress WNT signaling to maintain stable stem cell populations. BMPR1A null mice died at embyonic day 8.0 without mesoderm specification, demonstrating its vital role in gastrulation.cite journal | author = Mishina Y, Starbuck MW, Gentile MA, Fukuda T, Kasparcova V, Seedor JG, Hanks MC, Amling M, Pinero GJ, Harada S, Behringer RR | title = Bone morphogenetic protein type IA receptor signaling regulates postnatal osteoblast function and bone remodeling | journal = J. Biol. Chem. | volume = 279 | issue = 26 | pages = 27560–6 | year = 2004 | pmid = 15090551 | doi = 10.1074/jbc.M404222200 | issn = ] It has been demonstrated in experiments using dominant negative BMPR1A chick embryos that BMPR1A plays a role in apoptosis and adipocyte development. Using constitutively active forms of BMR1A it has been shown that it plays a role in cell differentiation. Signals tranduced by the BMPR1A receptor are not essential for osteoblast formation or proliferation; however, BMPR1A is necessary for the extracellular matrix depostition by osteoblasts. In the chick embryo, BMPR1A receptors are found in low levels in limb bud mesenchyme, a differing location to BMPR1B, supporting the differing roles they play in osteogenesis.cite journal | author = Yoon BS, Ovchinnikov DA, Yoshii I, Mishina Y, Behringer RR, Lyons KM | title = Bmpr1a and Bmpr1b have overlapping functions and are essential for chondrogenesis in vivo | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 102 | issue = 14 | pages = 5062–7 | year = 2005 | pmid = 15781876 | doi = 10.1073/pnas.0500031102 | issn = ]

Diseases

BMPR1A, SMAD4 and PTEN are responsible for Juvenile polyposis syndrome, juvenile intestinal polyposis and Cowden's disease.

References

External links

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Category:S/T domain