Endothelin receptor

Endothelin receptor

protein
Name=endothelin receptor type A
caption=


width=
HGNCid=3179
Symbol=EDNRA
AltSymbols=
EntrezGene=1909
OMIM=131243
RefSeq=NM_001957
UniProt=P25101
PDB=
ECnumber=
Chromosome=4
Arm=q
Band=31.2
LocusSupplementaryData=protein
Name=endothelin receptor type B
caption=


width=
HGNCid=3180
Symbol=EDNRB
AltSymbols=HSCR2, HSCR
EntrezGene=1910
OMIM=131244
RefSeq=NM_000115
UniProt=P24530
PDB=
ECnumber=
Chromosome=13
Arm=q
Band=22
LocusSupplementaryData=There are at least three known endothelin receptors, ETA, ETB1 and ETB2, all of which are G protein-coupled receptors whose activation result in elevation of intracellular-free calcium.cite journal | author = Davenport AP | title = International Union of Pharmacology. XXIX. Update on endothelin receptor nomenclature | journal = Pharmacol. Rev. | volume = 54 | issue = 2 | pages = 219–26 | year = 2002 | pmid = 12037137 | doi = 10.1124/pr.54.2.219 | issn = ]

Clinical significance

It is associated with ABCD syndromecite journal | author = Verheij JB, Kunze J, Osinga J, van Essen AJ, Hofstra RM | title = ABCD syndrome is caused by a homozygous mutation in the EDNRB gene | journal = Am. J. Med. Genet. | volume = 108 | issue = 3 | pages = 223–5 | year = 2002 | pmid = 11891690 | doi = 10.1002/ajmg.10172 | issn = ] and some forms of Waardenburg syndrome.cite journal | author = Read AP, Newton VE | title = Waardenburg syndrome | journal = J. Med. Genet. | volume = 34 | issue = 8 | pages = 656–65 | year = 1997 | pmid = 9279758 | doi = | issn = ]

ee also

* Endothelin receptor antagonist

References

External links

* [http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1283 IUPHAR GPCR Database - Endothelin Receptors]
*MeshName|Endothelin+receptor


Wikimedia Foundation. 2010.

Игры ⚽ Нужно сделать НИР?

Look at other dictionaries:

  • Endothelin receptor type B — Endothelin receptor type B, also known as EDNRB, is a human gene.Endothelin receptor type B is a G protein coupled receptor which activates a phosphatidylinoitol calcium second messenger system. Its ligand, endothelin, consists of a family of… …   Wikipedia

  • Endothelin receptor type A — Endothelin receptor type A, also known as EDNRA, is a human gene which encodes a G protein coupled receptor.cite web | title = Entrez Gene: EDNRA endothelin receptor type A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene… …   Wikipedia

  • Endothelin receptor antagonist — A endothelin receptor antagonist (ERA) is a drug which blocks endothelin receptors. Two main kinds of ERAs exist: * selective ERA (e.g. sitaxsentan), which affect endothelin A. * dual ERAs,(e.g. bosentan) which affect both endothelin A and B . [… …   Wikipedia

  • endothelin receptor — There are thought to be two G protein coupled receptors for endothelin, ET(A) (427 residues) and ET(B) (427 residues in human), present on vascular smooth muscle cells mediating vasoconstriction, and on endothelium mediating nitric oxide release …   Dictionary of molecular biology

  • endothelin receptor antagonist — A drug that blocks the hormone endothelin and may prevent prostate cancer from spreading to the bones. It may also prevent the growth and spread of other types of cancer, including colorectal cancer …   English dictionary of cancer terms

  • Endothelin 3 — Endothelin 3, also known as EDN3, is a human gene.cite web | title = Entrez Gene: EDN3 endothelin 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=1908| accessdate = ] PBB Summary section title = summary… …   Wikipedia

  • Endothelin — protein Name = Endothelin 2 width = caption = Symbol = EDN2 AltSymbols = ATC prefix= ATC suffix= ATC supplemental= CAS number= CAS supplemental= DrugBank= EntrezGene = 1907 HGNCid =3177 OMIM = 131241 PDB = RefSeq = NM 001956 UniProt = P20800… …   Wikipedia

  • Receptor antagonist — This article is about the biochemistry term. For other uses, see Antagonist (disambiguation). Antagonists will block the binding of an agonist at a receptor molecule, inhibiting the signal produced by a receptor agonist coupling. A receptor… …   Wikipedia

  • endothelin-1 protein receptor antagonist — A substance that blocks the binding of the endothelin 1 protein to its receptor. Endothelin 1 is a small molecule that causes changes in blood vessels and helps regulate blood pressure. It can also stimulate the growth of some types of cells …   English dictionary of cancer terms

  • NK1 receptor antagonist — Neurokinin 1 (NK1) antagonists are a novel class of medications that possesses unique antidepressant,[1] anxiolytic,[2] and antiemetic properties. The discovery of neurokinin 1 (NK1) receptor antagonists was a turning point in the prevention of… …   Wikipedia

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”