Physalaemin

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ImageFile=Physalaemin.svg
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CASNo=2507-24-6
PubChem=17268
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MeSHName=Physalaemin
Section2= Chembox Properties
Formula=C₅₈H₈₄N₁₄O₁₆S
MolarMass=1265.44 g/mol
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Physalaemin is a tachykinin peptide obtained from the "Physalaemus" frog, closely related to substance P. Its structure was first elucidated in 1964. [cite journal |author=Erspaemer V, Anastasi A, Bertaccini G, Cei JM |title=Structure and pharmacological actions of physalaemin, the main active polypeptide of the skin of Physalaemus fuscumaculatus |journal=Experientia |volume=20 |issue=9 |pages=489–90 |year=1964 |pmid=5857249 |doi=] [cite journal |author=Anastasi A, Erspamer V, Cei JM |title=Isolation and amino acid sequence of physalaemin, the main active polypeptide of the skin of Physalaemus fuscumaculatus |journal=Arch Biochem Biophys |volume=108 |issue= |pages=341–8 |year=1964 |pmid=14240587 |doi=]

Like all tachykinins, physalaemin is a sialagogue (increases salivation) and a potent vasodilator with hypotensive effects. [cite journal |author=Severini C, Improta G, Falconieri-Erspamer G, Salvadori S, Erspamer V |title=The tachykinin peptide family |journal=Pharmacol Rev |volume=54 |issue=2 |pages=285–322 |year=2002 |pmid=12037144 |doi= [http://pharmrev.aspetjournals.org/cgi/content/full/54/2/285 Free full text] ]

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