Avermectin

Avermectin

Avermectin is a family of anti-parasitic drugs whose analogues include ivermectin, selamectin, doramectin and abamectin.

Avermectin therapy for rodent fur mite infestation

A commonly used therapy in recent times has been based on oral or parenteral administration of avermectins, which are macrocyclic lactones produced by fermentation of the soil micro-organism "Streptomyces avermitilis". They show activity against a broad range of nematodes and arthropod parasites of domestic animals at dose rates of 300 microgram/kg or less. Unlike the macrolide or polyene antibiotics, they lack significant antibacterial or antifungal activity (Hotson, 1982).

Other Uses

Avermectin B1 is the active ingredient in some commercial ant bait traps.

References

* Hotson IK, 1982, The avermectins: A new family of antiparasitic agents, J S Afr Vet Assoc., Jun;53(2):87-90.
* Clark JM, 1995, with Scott JG, Campos F, Bloomquist JR, Resistance to avermectins: extent, mechanisms, and management implications, Annu Rev Entomol, 40:1-30.
* Toth LA, 2000, with Oberbeck C, Straign CM, Frazier S, Rehg JE, Toxicity evaluation of prophylactic treatments for mites and pinworms in mice, Contemp Top Lab Anim Sci., Mar;39(2):18-21.
* Viktorov AV, 2003, with Yurkiv VA, Effect of ivermectin on function of liver macrophages, Bull Exp Biol Med., Dec;136(6):569-71.


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Look at other dictionaries:

  • avermectin B1 — (= abamectin) Metabolite of Streptomyces avermitilis used as an acaricide, insecticide and anthelminthic …   Dictionary of molecular biology

  • avermectin — noun Any of a class of macrocyclic lactones, produced by Streptomyces bacteria, that are used medically to kill parasites …   Wiktionary

  • Avermectin — A|ver|mec|tin [Kunstw., zu Streptomyces avermitilis], das; s, e: eine Gruppe von antiparasitisch u. anthelmintisch wirksamen pentacycl. ↑ Makroliden mit einem 16 gliedrigen Lactonring u. zwei Oleandroseeinheiten. Vgl. Ivermectin …   Universal-Lexikon

  • avermectin — av·er·mec·tin (av″ər mekґtin) any of a group of lactones that are potent anthelmintics and insecticides …   Medical dictionary

  • avermectin — n. any one of the group of lactones that are potent anthelmintics for humans and insecticides for domestic animals …   English contemporary dictionary

  • avermectin — [ˌeɪvə mɛktɪn] noun Medicine any of a group of macrocyclic compounds isolated from a strain of bacteria, used to destroy parasitic worms. Origin 1970s: from mod. L. (Streptomyces) averm(itilis), the name of the source bacterium, + ect + in1 …   English new terms dictionary

  • Abamectin — is a mixture of avermectins containing more than 80% avermectin B1a and less than 20% avermectin B1b . These two components, B1a and B1b have very similar biological and toxicological properties. The avermectins are insecticidal or anthelmintic… …   Wikipedia

  • 70288-86-7 — Ivermectine Ivermectine Général Nom IUPAC Ivermectine (22,23 dihydroavermectin B1a + 22,23 dihydroavermectin B1b) …   Wikipédia en Français

  • C47H72O14 — Ivermectine Ivermectine Général Nom IUPAC Ivermectine (22,23 dihydroavermectin B1a + 22,23 dihydroavermectin B1b) …   Wikipédia en Français

  • C48H74O14 — Ivermectine Ivermectine Général Nom IUPAC Ivermectine (22,23 dihydroavermectin B1a + 22,23 dihydroavermectin B1b) …   Wikipédia en Français

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