Sister chromatid exchange
- Sister chromatid exchange
Sister chromatid exchange (SCE) is the exchange of genetic material between two identical sister chromatids.
It was first discovered by using the giemsa staining method on one chromatid belonging to the sister chromatid complex before anaphase in mitosis. The staining revealed that few segments were passed to the sister chromatid which were not dyed.The giemsa staining was able to stain due to the presence of bromodeoxyuridine anologous base which was introduced to the desired chromatid.
The reason for the (SCE) is not known but it is required and used as a mutagenic testing of many products. Four to five sister chromatid exchange is in the normal distribution, 14-100 exchanges is not normal and presents a danger to the organism.
Bloom syndrome is closely related to it, having 100 to 160 s.c.e. SCE. may also be related to tumors.
Sister chromatid exchange has also been observed more frequently in B51(+) Behçet's disease.[cite journal |author=Ikbal M, Atasoy M, Pirim I, Aliagaoglu C, Karatay S, Erdem T |title=The alteration of sister chromatid exchange frequencies in Behçet's disease with and without HLA-B51 |journal=J Eur Acad Dermatol Venereol |volume=20 |issue=2 |pages=149–52 |year=2006 |month=February |pmid=16441621 |doi=10.1111/j.1468-3083.2006.01386.x |url=] ]External links
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References
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Look at other dictionaries:
sister-chromatid exchange — noun Reciprocal exchange of DNA between the chromatids of a single chromosome • • • Main Entry: ↑sister … Useful english dictionary
sister chromatid exchange — the exchange of segments of DNA between sister chromatids, which is common in patients with Bloom syndrome … Medical dictionary
sister chromatid exchange — Abbreviation: SCE Reciprocal interchanges of the two chromatid arms within a single chromosome … Glossary of Biotechnology
exchange — To substitute one thing for another, or the act of such substitution. sister chromatid e. the e. during mitosis of homologous genetic material between sister chromatids; increased as a result of inordinate chromosomal fragility … Medical dictionary
SCER — sister chromatid exchange rate … Medical dictionary
SCER — • sister chromatid exchange rate … Dictionary of medical acronyms & abbreviations
SCE-Färbung — Schema eines Schwesterchromatidaustauschs. Im unteren Bereich sind die Enden der Chromatiden vertauscht … Deutsch Wikipedia
SCE-Test — Schema eines Schwesterchromatidaustauschs. Im unteren Bereich sind die Enden der Chromatiden vertauscht … Deutsch Wikipedia
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Homologous recombination — Figure 1. During meiosis, homologous recombination can produce new combinations of genes as shown here between similar but not identical copies of human chromosome 1. Homologous recombination is a type of genetic recombination in which nucleotide … Wikipedia
