Zoonosis

A zoonosis (pronEng|ˌzoʊəˈnoʊsɨs) or zoonose is any infectious disease that is able to be transmitted (by a vector) from other animals, both wild and domestic, to humans or from humans to animals (the latter is sometimes called reverse zoonosis). The word is derived from the Greek words "zòon" (animal) and "nosos" (ill). Many serious diseases fall under this category.

The simplest definition of a zoonosis is a disease that can be transmitted from other vertebrate animals to humans. A slightly more technical definition is a disease that normally exists in other animals, but also infects humans.

The emerging interdisciplinary field of conservation medicine, which integrates human and veterinary medicine, and environmental sciences, is largely concerned with zoonoses.

Partial list of carriers

A partial list of agents that can carry infectious organisms that may be zoonotic includes
* Assassin bugs
* Bats
* Bank voles
* Birds
* Cats
* Cattle
* Chimpanzees
* Dogs
* Fish
* Fleas
* Flies
* Geese
* Goats
* Hamsters
* Horses
* Humans
* Lice
* Mice
* Monkeys
* Mosquitos
* Opossums
* Pigs
* Rabbits and hares
* Raccoons
* Rats
* Rodents
* Sloths
* Sheep
* Snails
* Ticks

List of infectious agents

Zoonoses can be listed according to the infectious agent:
* Parasites
** protozoa, helminths (cestodes and trematodes)
* Fungi
* Bacteria
* Viruses
* Pria

Partial list of zoonoses

* Anthrax
* Avian Influenza (Bird Flu)
* Babesiosis
* Barmah Forest virus
* Bartonellosis
* Bilharzia
* Bolivian hemorrhagic fever
* Brucellosis
* Borrelia (Lyme disease and others)
* Borna virus infection
* Bovine tuberculosis
* Campylobacteriosis
* Chagas disease
* Chlamydophila psittaci
* Cholera
* Cowpox
* Creutzfeldt-Jakob disease (vCJD),:a transmissible spongiform encephalopathy (TSE):from bovine spongiform encephalopathy (BSE) or "mad cow disease"
* Crimean-Congo hemorrhagic fever
* Cryptosporidiosis
* Cutaneous larva migrans
* Dengue fever
* Ebola
* Echinococcosis
*
* Eastern equine encephalitis virus
* Western equine encephalitis virus
* Venezuelan equine encephalitis virus
* Hantavirus
* Hendra virus
* Henipavirus
* Korean hemorrhagic fever
* Kyasanur forest disease
* Lábrea fever
* Lassa fever
* Leishmaniasis
* Leptospirosis
* Listeriosis
* Lymphocytic choriomeningitis virus
* Malaria
* Marburg fever
* Mediterranean spotted fever
* Monkey B
* Nipah fever
* Ocular larva migrans
* Omsk hemorrhagic fever
* Ornithosis (psittacosis)
* Orf (animal disease)
* Oropouche fever
* Plague
* Puumala virus
* Q-Fever
* Psittacosis, or "parrot fever"
* Rabies
* Rift Valley fever
* Ringworms ("Tinea canis")
* Salmonellosis
* Sodoku
* Streptococcus suis
* Toxoplasmosis
* Trichinosis
* Tularemia, or "rabbit fever"
* Typhus of Rickettsiae
* Venezuelan hemorrhagic fever
* Visceral larva migrans
* West Nile virus
* Yellow fever

Other zoonoses might be:
* Glanders
* SARS (possibly; civet cats may spread the disease, or may catch the disease from humans.)

This list is by no means complete. The influenza virus is an interesting example: It continually recombines genes between strains found in humans, swine and avians, producing new strains with changed characteristics, and occasionally, as in 1918, killing millions worldwide.

Historical development of zoonotic diseases

Most of human prehistory was spent as small bands of hunter-gatherers; these bands were rarely larger than 150 individuals, and were not in contact with other bands very often. Because of this, epidemic or pandemic diseases, which depend on a constant influx of humans who have not developed an immune response, tended to burn out after their first run through a population. To survive, a biological pathogen had to be a chronic infection, stay alive in the host for long whiles, or have a non-human reservoir in which to live while waiting for new hosts to pass by. In fact, for many 'human' diseases, the human is actually an accidental victim and a dead-end host. (This is the case with rabies, anthrax, tularemia, West Nile virus, and many others). Thus much of human development has been in relation to zoonotic, not epidemic, diseases.

Many modern diseases, even epidemic diseases, started out as zoonotic diseases. It is hard to be certain which diseases jumped from other animals to humans, but there is good evidence that measles, smallpox, influenza, HIV, and diphtheria came to us this way. The common cold, and tuberculosis may also have started in other species.

In modern days, zoonoses are of practical interest because they are often previously unrecognized diseases or have increased virulence in populations lacking immunity. The West Nile virus appeared in the United States in 1999 in the New York City area, and moved through the country in the summer of 2002, causing much distress. Bubonic plague is a zoonotic disease, as are salmonella, Rocky Mountain spotted fever, and Lyme disease.

The major factor contributing to the appearance of new zoonotic pathogens in human populations is increased contact between humans and wildlife (Daszak "et al"., 2001). This can be caused either by encroachment of human activity into wilderness areas or by movement of wild animals into areas of human activity due to anthropological or environmental disturbances. An example of this is the outbreak of Nipah virus in peninsular Malaysia in 1999, when intensive pig farming intruded into the natural habitat of fruit bats carrying the virus. Unidentified spillover events caused infection of the pig population which acted as an amplifier host, eventually transmitting the virus to farmers and resulting in 105 human deaths (Field "et al"., 2001).

Similarly, in recent times avian influenza and West Nile virus have spilled over into human populations probably due to interactions between the carrier host and domestic animals. Highly mobile animals such as bats and birds may present a greater risk of zoonotic transmission than other animals due to the ease with which they can move into areas of human habitation.

Diseases like malaria, schistosomiasis, river blindness, and elephantiasis are "not" zoonotic, even though they may be transmitted by insects or use intermediate hosts vectors, because they depend on the human host for part of their life-cycle.

Partial list of outbreaks of zoonosis associated with fairs and petting zoos

Outbreaks of zoonosis have been traced to human interaction with and exposure to animals at fairs, petting zoos, and in other settings. In 2005, the Centers for Disease Control and Prevention (CDC) issued an updated list of recommendations for preventing zoonosis transmission in public settings. [cite journal |author=Centers for Disease Control and Prevention |title= Compendium of Measures To Prevent Disease Associated with Animals in Public Settings, 2005: National Association of State Public Health Veterinarians, Inc. (NASPHV) |journal=MMWR |volume= 54 |issue=No. RR-4 |pages=inclusive page numbers |year=2005 |url=http://www.cdc.gov/mmwr/PDF/rr/rr5404.pdf] The CDC recommendations, which were developed in conjunction with the [http://www.nasphv.org/ National Association of State Public Health Veterinarians] , include sections on the educational responsibilities of venue operators, managing public and animal contact, and animal care and management.

In 1988, a person became ill with Swine Influenza Virus (Swine Flu) and died after visiting the display area of the pig barn at a Wisconsin county fair. Three healthcare personnel treating the case patient also developed flu-like illness with laboratory evidence of Swine Influenza Virus infection. [cite journal |author=Wells, et al. |title=Swine influenza virus infections. Transmission from ill pigs to humans at a Wisconsin agricultural fair and subsequent probable person-to-person transmission |journal=JAMA |volume=265 |issue=4 |pages=481 |year=1991 | doi = 10.1001/jama.265.4.478 ] Investigators from the CDC indicated in their final report that the Swine Flu had been transmitted directly from pig to human host. [cite journal |author=Centers for Disease Control and Prevention |title=Human infection with swine influenza virus – Wisconsin |journal=MMWR |volume=37 |issue=43 |pages=661–3 |url= http://www.cdc.gov/MMWR/preview/mmwrhtml/00021592.htm ]

In 1994, seven cases of "E. coli" O157:H7 infection were traced to a farm in Leicestershire, United Kingdom. An epidemiological investigation into the outbreak revealed that the strain of "E. coli" O157:H7 isolated from nine animals on the farm was indistinguishable from the strain isolated from human samples. Investigators concluded that the most likely cause of this outbreak was direct human contact with animals. [cite journal |author=Shukla, et al. |title=’’Escherichia coli’’ O157 infection associated with a farm visitor center |journal=Communicable Disease Report |volume=5 |issue=6 |pages=R86–R90]

In 1995, 43 children who had visited a rural farm in Wales became ill with Cryptosporidiosis. ‘’Cryptosporidium’’ was isolated from seven of the ill children. An epidemiological investigation indicated that the source of the children’s illness was contact with calves at the farm. [cite journal |author=Evans, M. R. and D. Gardner |title=’’Cryptosporidiosis’’ Outbreak Associated with an Educational Farm Holiday |journal=Commun Dis Rep CDR Rev. 29 |volume=6 |issue=4 |pages=R67 |year=1996 |id=ISSN: 1350-9349]

Also in 1995, at least thirteen children became ill with ‘’Cryptosporidiosis’’ after visiting a farm in Dublin, Ireland. In a case-control study, researchers compared the activities of the thirteen ill children, or cases, to the activities of 52 out of 55 people who had visited the farm – the controls. The study revealed that illness was significantly associated with playing in the sand in a picnic area beside a stream where animals had access. [cite journal |author=Sayers, et al. |title=Cryptosporidiosis in children who visited an open farm. |journal=Commun Dis Rep CDR Rev. 13 |volume=6 |issue=10 |pages=R140–4 |year=1996]

In 1997, an "E. coli" O157:H7 outbreak was identified among one child who lived on an open farm and two children who visited the farm during school parties. Two of the three children developed hemolytic-uremic syndrome (HUS). Isolates collected from the three children and from samples taken at the farm were indistinguishable, demonstrating evidence of the link between the farm and the children’s illness. [cite journal |author=Milne, et al. |title=’’Escherichia coli’’ O157 incident associated with a farm open to members of the public |journal= Communicable Disease and Public Health |pages=22–26 |year=1999 |volume=2]

In 1999, what is believed to be the largest outbreak of waterborne "E. coli" O157:H7 illness in United States history occurred at the Washington County, New York fair. The [http://www.health.state.ny.us/ New York State Department of Health] identified 781 individuals who were suspected of being infected with either "E. coli" O157:H7 or "Campylobacter jejuni". An investigation into the outbreak revealed that consumption of beverages purchased from vendors supplied with water drawn from an unchlorinated fairgrounds well was associated with illness. In all, 127 outbreak victims were confirmed ill with "E. coli" O157:H7 infections; 71 were hospitalized, 14 developed HUS, and two died. [cite paper |author=New York State Department of Health and A.C. Novello |title=The Washington County Fair outbreak report |year=2000]

In 2000, 51 people became ill with confirmed or suspected "E. coli" O157:H7 infections after visiting a dairy farm in Pennsylvania. Eight children developed HUS. A case-control study among visitors to the dairy was conducted jointly by the CDC, [http://www.dsf.health.state.pa.us/health/site/default.asp Pennsylvania Department of Health] , and the Montgomery County Health Department. The study’s authors concluded that "E. coli" was transmitted to visitors as a result of contamination on animal hides and in the environment. [cite journal |author=Centers for Disease Control and Prevention |title=Outbreaks of ‘’Escherichia coli’’ O157:H7 infections among children associated with farm visits—Pennsylvania and Washington 2000 |journal=MMWR |volume=50 |issue=15 |pages=293–297 |year=2001 |url= http://www.cdc.gov/mmwR/preview/mmwrhtml/mm5015a5.htm]

Also in 2000, 43 visitors to the Medina County fair in Ohio were confirmed ill with "E. coli" O157:H7 infections. An investigation into the outbreak suggested that the water system from which food vendors were supplied was the source of the "E. coli" outbreak. Several months later, five children became ill with "E. coli" infections after attending a “Carnival of Horrors” event held at the Medina County fairgrounds. PFGE analysis of the strains of "E. coli" isolated from members of both outbreaks revealed an indistinguishable pattern, and investigators from the [http://www.medinahealth.org/ Medina County Health Department] and the CDC determined that the Medina County Fairgrounds water distribution system was the source of both "E. coli" outbreaks. [cite paper |author=Rickelman-Apisa, J.M. |title=Summary of "E. coli" O157:H7 Outbreak Associated with the Medina County Fairgrounds 2000 Fair and 2000 Carnival of Horrors |publisher=Medina County Health Department |date=2001-09-28]

In 2001, an "E. coli" O157:H7 outbreak was traced to exposure in the Cow Palace at the Lorain County Fair in Ohio. CDC investigators identified 23 cases of "E. coli" infection associated with attendance at the Lorain County Fair, with additional secondary cases likely. Two people developed HUS. An environmental and site investigation revealed "E. coli" contamination on doorways, rails, bleachers, and sawdust. Investigators concluded that the Lorain County Fair was the source of the outbreak.cite paper |author= Varma, J.K. |title=Trip report epi-aid # 2001-84: Outbreaks of E. coli O157:H7 infections associated with Lorain and Wyandot County fairs, Ohio, September-October 2002 From Jay K. Varma, EIS officer, Food borne and Diarrheal Diseases branch to Forrest Smith, State Epidemiologist, Ohio department of Health. |publisher= Public Health Service. Department of Health and Human Services |date=2002-02-15]

Wyandot County, Ohio, also reported an "E. coli" O157:H7 outbreak in 2001. Ninety-two "E. coli" infections were reported to the [http://www.wyandothealth.com/ Wyandot County Health Department] and the CDC, with 27 cases confirmed using laboratory analysis. Two cases developed HUS. Contact with infected cattle was believed to be the source of the outbreak; however, a specific cause was never identified.cite paper |author= Varma, J.K. |title=Trip report epi-aid # 2001-84: Outbreaks of E. coli O157:H7 infections associated with Lorain and Wyandot County fairs, Ohio, September-October 2002 From Jay K. Varma, EIS officer, Food borne and Diarrheal Diseases branch to Forrest Smith, State Epidemiologist, Ohio department of Health. |publisher= Public Health Service. Department of Health and Human Services |date=2002-02-15]

In 2002, seven people became ill with "E. coli" O157:H7 infections after visiting a large agricultural fair in Ontario, Canada. Outbreak investigators conducted a case-control study, which indicated that goats and sheep from a petting zoo were the source of the "E. coli" among fair visitors. Other indications were that the fencing and environment surrounding the petting zoo could have been a source of transmission. [cite journal |author=Warshawsky, et al. |title=Outbreak of "Escherichia coli" O157:H7 related to animal contact at a petting zoo |journal=Canadian Journal of Infectious Diseases |volume=13 |issue=3 |pages=175–181]

What is believed to be the largest "E. coli" O157:H7 outbreak in Oregon State history occurred among attendees at the Lane County Fair in 2002. [cite journal |author=Oregon Department of Human Services |title=Hemorrhagic Escherichiosis from a County Fair |journal=CD Summary |volume=51 |issue=19 |date=2002-09-13 url=http://www.oregon.gov/DHS/ph/cdsumMarchy/2002/ohd5119.pdf |accessdate=2007-05-22|format=PDF] An [http://www.oregon.gov/DHS/ph/index.shtml Oregon Department of Human Services – Health Services] investigation led to the belief that the "E. coli" outbreak originated from exposure in the sheep and goat barn. In all, 79 people were confirmed ill with "E. coli" infections as part of the outbreak; 22 were hospitalized, and 12 suffered HUS. [cite paper |author=Oregon Department of Human Services, Health Services |title=2005 Ways and Means Presentation – Phase 1 |publisher=Oregon Department of Human Services |date=2005 |url=http://www.oregon.gov/DHS/aboutdhs/budget/0507budget/w-m_ph_ph1_ov.pdf |format=pdf |accessdate=2007-05-22]

In 2003, fair visitors and animal exhibitors at the Fort Bend County Fair in Texas became ill with "E. coli" O157:H7 infections. An outbreak investigation led to the determination that 25 people had become ill with "E. coli" infections after attending the Fort Bend County Fair; seven people were laboratory-confirmed with "E. coli", and 5 developed HUS or TTP (Thrombotic thrombocytopenic purpura). Investigators isolated a strain of "E. coli" indistinguishable from the outbreak strain from four animal husbandry sites, and found high levels of "E. coli" contamination in both rodeo and animal exhibit areas. [cite journal |author=Durso, L.M., et al. |title=Shiga-Toxigenic "Escherichia coli" (STEC) O157:H7 Infections Among Livestock Exhibitors and Visitors at a Texas County Fair |journal=Vector-Borne And Zoonotic Diseases |volume=5 |pages=193–201 |year=2005 | doi = 10.1089/vbz.2005.5.193 ]

In 2004, a large "E. coli" O157:H7 outbreak occurred among visitors at the 2004 North Carolina State Fair. During its investigation into the outbreak, the [http://www.dhhs.state.nc.us/ North Carolina Department of Health and Human Services (NCDHHS)] received over 180 reports of illness, and documented 33 culture-confirmed cases of "E. coli" O157:H7 associated with attendance at the fair, with 15 children developing HUS. In its final investigation report, NCDHHS concluded that the North Carolina State Fair "E. coli" outbreak had originated at a petting zoo exhibit. The conclusion was supported by a case-control study, environmental sampling, and laboratory analysis of samples collected from the fair and members of the outbreak. [cite paper |last=Goode |first=B. |coauthors=O'Reilly, C. |title=Outbreak of Shiga toxin producing "E. coli" (STEC) infections associated with a petting zoo at the North Carolina State Fair – Raleigh, North Carolina, November 2004 Final Report |publisher=North Carolina Department of Health and Human Services |date=2005-06-29]

In 2005, a petting zoo that exhibited at two Florida fairs and a festival was traced as the source of an "E. coli" O157:H7 outbreak. Sixty-three people who had visited either the Florida State Fair, the Central Florida Fair, or the Florida Strawberry Festival reported illness to investigators for the [http://www.doh.state.fl.us/ Florida Department of Health] , including 20 who were culture-confirmed and 7 with HUS. A case-control study revealed that illness was associated with exposure to a petting zoo exhibit present at all three events. [cite journal |author=Centers for Disease Control and Prevention |title=Outbreaks of "Escherichia coli" O157:H7 Associated with Petting Zoos — North Carolina, Florida, and Arizona, 2004 and 2005 |journal=MMWR |volume=54 issue= 50 |pages=1279 |year=2005]

Contribution of zoonotic pathogens to foodborne illness

The most significant zoonotic pathoges that cause the foodborne diseases are those of , "Campylobacter", "Caliciviridae", and "Salmonella".cite journal
last = Humphrey
first = Tom "et al."
authorlink =
coauthors =
title = Campylobacters as zoonotic pathogens: A food production perspective
journal = International Journal of Food Microbiology
volume = 117
issue = 3
pages = 237–257
publisher =
date = 2007
url =
doi = 10.1016/j.ijfoodmicro.2007.01.006
accessdate = 5 April
accessyear = 2008
] cite journal
last = Cloeckaert
first = Axel
authorlink =
coauthors =
title = Introduction: emerging antimicrobial resistance mechanisms in the zoonotic foodborne pathogens Salmonella and Campylobacter
journal = Microbes and Infection
volume = 8
issue = 7
pages = 1889–1890
publisher =
date = 2006
url =
doi = 10.1016/j.micinf.2005.12.024
accessdate = 5 April
accessyear = 2008
] cite web
last = Frederick
first = A. Murphy
authorlink =
coauthors =
title = The Threat Posed by the Global Emergence of Livestock, Food-borne, and Zoonotic Pathogens
work =
publisher =
date =
url = http://www.annalsonline.org/cgi/content/citation/894/1/20
format =
doi =
accessdate = 5 April
accessyear = 2008
]

In 2006, a conference held in Berlin was focusing on the issue of zoonotic pathogen effects on food safety, urging governments to intervene the problem, and the public to be vigilant towards the risks of catching food-borne diseases via the route of farm-to-dining table.cite web
last = Med-Vet-Net
first =
authorlink =
coauthors =
title = Priority Setting for Foodborne and Zoonotic Pathogens
work =
publisher =
date =
url = http://www.medvetnet.org/pdf/Reports/Report_07-001.pdf
format =
doi =
accessdate = 5 April
accessyear = 2008
]

Bibliography

*Field, H., Young, P., Yob, J. M., Mills, J., Hall, L., Mackenzie, J. (2001). The natural history of Hendra and Nipah viruses. "Microbes and Infection" 3, 307–314.
*Daszak, P., Cunningham, A.A., Hyatt, A.D. (2001). Anthropogenic environmental change and the emergence of infectious diseases in wildlife. "Acta Trop." 78(2), 103–116.
*H. Krauss, A. Weber, M. Appel, B. Enders, A. v. Graevenitz, H. D. Isenberg, H. G. Schiefer, W. Slenczka, H. Zahner: Zoonoses. Infectious Diseases Transmissible from Animals to Humans. 3rd Edition, 456 pages. ASM Press. American Society for Microbiology, Washington DC., USA. 2003. ISBN 1-55581-236-8

References

ee also

*Human parasitic diseases
*Foodborne illness
*Quantitative microbiological risk assessments
*Spanish flu
*Zoophilia
*Zoophilia and health
*Disinsection
*Disinfection
*Deratization

External links

* [http://digitalcommons.unl.edu/zoonoticspub/ Publications in Zoonotics and Wildlife Disease]


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