- Alfons Maria Jakob
Alfons Maria Jakob (
July 2, 1884, Aschaffenburg/ Bavaria– October 17, 1931, Hamburg) was a German neurologistwith important contributions on neuropathology.
Alfons Maria Jakob was the son of a shopkeeper. He studied
medicinein Munich, Berlin, and Strasbourg, where obtained his doctorate in 1908. In 1909 he commenced clinical work under the psychiatrist Emil Kraepelinand did laboratory work with Franz Nissland Alois Alzheimerin Munich.
In 1911 he went to
Hamburgto work with Theodor Kaesand became head of the laboratory of anatomical pathologyat the psychiatric State Hospital Hamburg-Friedrichsberg. Following the death of Kaes in 1913, Jakob succeeded him as prosector. After serving in the German army in World War I, he returned to Hamburg and climbed the academic ladder. He was habilitated in neurologyin 1919 and in 1924 became professor of neurology. Under Jakob's guidance the department grew rapidly. He made notable contributions to knowledge on concussionand secondary nerve degeneration and became a doyen of neuropathology.
Jakob published five monographs and more than 75 papers. His neuropathological studies contributed greatly to the delineation of several diseases, including
multiple sclerosisand Friedreich's ataxia. He first recognised and described Alper's diseaseand Creutzfeldt-Jakob disease(the latter with Hans Gerhard Creutzfeldt). He accumulated immense experience in neurosyphilis, having a 200-bedded ward devoted exclusively to that disorder. Jakob made a lecture tour of the U.S.A.and South-Americawhere he wrote a paper on the neuropathology of yellow fever.
He suffered from chronic
osteomyelitisfor the last 7 years of his life. This eventually caused a retroperitoneal abscessand paralytic ileusfrom which he died following operation.
Creutzfeldt-Jakob disease: A very rare and incurable form of transmissible spongiform encephalopathiescaused by prions.
* "Die extrapyramidalen Erkrankungen". In: "Monographien aus dem Gesamtgebiete der Neurologie und Psychiatry", Berlin, 1923
* "Normale und pathologische Anatomie und Histologie des Grosshirns". Separate printing of "Handbuch der Psychiatry". Leipzig, 1927-1928
* "Das Kleinhirn". In: "Handbuch der mikroskopischen Anatomie", Berlin, 1928
* "Die Syphilis des Gehirns und seiner Häute". In: Oswald Bumke (edit.): "Hanbuch der Geisteskrankheiten", Berlin, 1930
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