DARPP-32

See PPP1R1B for full information on this gene.

DARPP-32 stands for dopamine- and cyclic AMP-regulated phosphoprotein with molecular weight 32 kDa. DARPP-32 is also the name of the gene that creates the protein.

It was discovered by Paul Greengard and co-workers.

DARPP32 is related to dopamine [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16189209&query_hl=8] , glutamate and adenosine; and may be related to schizophrenia [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16199832&query_hl=8] , Parkinson's disease or EPS (Extra-pyramidal symptoms).

A considerable proportion of the psychomotor effects of cannabinoids can be accounted for by a signaling cascade in striatal projection neurons involving PKA-dependent phosphorylation of DARPP-32, achieved via modulation of dopamine D2 and adenosine A2A transmission [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16162925&query_hl=8] .

Currently there is strong evidence that DARPP-32 may be the shared chain in the action of multiple drugs including cocaine, amphetamine, nicotine, caffeine, LSD, PCP, ethanol and morphine [Svenningsson P, Nairn AC, Greengard P. DARPP-32 Mediates the Actions of Multiple Drugs of Abuse. AAPS Journal. 2005; 07(02): E353-E360. DOI: 10.1208/aapsj070235 [http://www.aapsj.org/view.asp?art=aapsj070235] ]

The DARPP-32 gene

A common version of the DARPP-32 gene has been shown to improve the transfer of information between the striatum and the prefrontal cortex. When this process works well it leads to improved and more flexible cognition.

However this same version of the gene has been linked to an increased risk of schizophrenia. While this gene typically improves cognitive ability, it may have a negative effect when other genetic and environmental factors interfere. [Henderson M. Schizophrenia could be evolution of the intellect News.com.au 2007 [http://www.news.com.au/story/0,23599,21201390-2,00.html free text] ]

External links

* [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=6501303&query_hl=5 An article in 1984 - Full free text available]
* [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16123776&query_hl=8 Action of Cocaine]
* [http://pn.psychiatryonline.org/cgi/content/full/37/18/24 DARPP-32 May Be Culprit In Schizophrenia Symptoms]

References