PB-28

PB-28
IUPAC name 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetra- hydronaphthalen-1-yl)propyl]piperazine
Other names PB28
Identifiers
CAS number	172906-90-0 Y
ChEMBL	CHEMBL53325 N
Jmol-3D images	Image 1
SMILES COc1c(CCCC2CCCN3CCN(C4CCCCC4)CC3)c2ccc1
Properties
Molecular formula	C24H38N2O
Molar mass	370.57 g/mol
N (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

PB-28^[1] is an agonist of the sigma-2 receptor.^{[2][3][4][5][6]}

It is derived from cyclohexylpiperazine.

References

1. ^ Berardi F, Colabufo NA, Giudice G, Perrone R, Tortorella V, Govoni S, Lucchi L (1996). "New sigma and 5-HT1A receptor ligands: omega-(tetralin-1-yl)-n-alkylamine derivatives". J. Med. Chem. 39 (1): 176–82. doi:10.1021/jm950409c. PMID 8568804. 
2. ^ Cassano G, Gasparre G, Contino M, Niso M, Berardi F, Perrone R, Colabufo NA (2006). "The sigma-2 receptor agonist PB28 inhibits calcium release from the endoplasmic reticulum of SK-N-SH neuroblastoma cells". Cell Calcium 40 (1): 23–8. doi:10.1016/j.ceca.2006.03.004. PMID 16687172. 
3. ^ Azzariti A, Colabufo NA, Berardi F, Porcelli L, Niso M, Simone GM, Perrone R, Paradiso A (2006). "Cyclohexylpiperazine derivative PB28, a sigma2 agonist and sigma1 antagonist receptor, inhibits cell growth, modulates P-glycoprotein, and synergizes with anthracyclines in breast cancer". Mol. Cancer Ther. 5 (7): 1807–16. doi:10.1158/1535-7163.MCT-05-0402. PMID 16891467. 
4. ^ Colabufo NA, Berardi F, Abate C, Contino M, Niso M, Perrone R (July 2006). "Is the sigma2 receptor a histone binding protein?". Journal of Medicinal Chemistry 49 (14): 4153–8. doi:10.1021/jm0600592. PMID 16821775. 
5. ^ Berardi F, Abate C, Ferorelli S, Uricchio V, Colabufo NA, Niso M, Perrone R (December 2009). "Exploring the importance of piperazine N-atoms for sigma(2) receptor affinity and activity in a series of analogs of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28)". Journal of Medicinal Chemistry 52 (23): 7817–28. doi:10.1021/jm9007505. PMID 19842660. 
6. ^ Abate C, Elenewski J, Niso M, Berardi F, Colabufo NA, Azzariti A, Perrone R, Glennon RA (February 2010). "Interaction of the sigma(2) receptor ligand PB28 with the human nucleosome: computational and experimental probes of interaction with the H2A/H2B dimer". Chemmedchem 5 (2): 268–73. doi:10.1002/cmdc.200900402. PMID 20077462. 

External links

• MeSH PB28+compound