Olah reagent

Olah reagent

The Olah reagent is a nucleophilic fluorinating agent. It consists of a mixture of 70% hydrogen fluoride and 30% pyridine; alcohols react with this reagent to give alkyl fluorides:

Olah' reagent.png

It acts as a stabilized, less volatile form of hydrogen fluoride. It's used in the fluorination of steroids and in deprotection of peptides.[1][2][3] Instead of hydrogen fluoride, several other flourinating agents can be used, such as diethylaminosulfur trifluoride (DAST).

Olah reaction example.png


See also

Ishikawa reagent
Organofluoride

References

  1. ^ C. G. Bergstrom et al., J. Org. Chem. 28, 2633 (1963)
  2. ^ G. A. Olah et al., Synthesis 1973, 779; idem et al., J. Org. Chem. 44, 3872 (1979).
  3. ^ Review of use in organic synthesis: G. A. Olah et al., J. Fluorine Chem. 33, 377-396 (1986).

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