Nolatrexed

Nolatrexed: Nolatrexed

IUPAC name

2-Amino-6-methyl-5-(4-pyridylthio)-1H-quinazolin-4-one

Identifiers

CAS number 147149-76-6

PubChem 108189

Jmol-3D images Image 1

SMILES

CC1=C(C2=C(C=C1)NC(=NC2=O)N)SC3=CC=NC=C3

Properties

Molecular formula C₁₄H₁₂N₄OS

Molar mass 284.34 g/mol

Y (verify) (what is: Y/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)

Infobox references

Nolatrexed is a thymidylate synthase inhibitor.^[1]

References

^ Hughes AN, Rafi I, Griffin MJ, et al. (January 1999). "Phase I studies with the nonclassical antifolate nolatrexed dihydrochloride (AG337, THYMITAQ) administered orally for 5 days". Clin. Cancer Res. 5 (1): 111–8. PMID 9918208. http://clincancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=9918208.

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Academic Dictionaries and Encyclopedias

Nolatrexed

IUPAC name 2-Amino-6-methyl-5-(4-pyridylthio)-1H-quinazolin-4-one
Identifiers
CAS number	147149-76-6
PubChem	108189
Jmol-3D images	Image 1
SMILES CC1=C(C2=C(C=C1)NC(=NC2=O)N)SC3=CC=NC=C3
Properties
Molecular formula	C₁₄H₁₂N₄OS
Molar mass	284.34 g/mol
Y (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references