NRG3

Neuregulin 3
Identifiers
Symbols	NRG3; HRG3; pro-NRG3
External IDs	OMIM: 605533 MGI: 1097165 HomoloGene: 32051 GeneCards: NRG3 Gene
Gene Ontology Molecular function • growth factor activity • transmembrane receptor protein tyrosine kinase activator activity • receptor tyrosine kinase binding Cellular component • extracellular region • plasma membrane • integral to plasma membrane Biological process • regulation of cell growth Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10718	18183
Ensembl	ENSG00000185737	ENSMUSG00000041014
UniProt	P56975	O35181
RefSeq (mRNA)	NM_001010848.3	NM_008734
RefSeq (protein)	NP_001010848.2	NP_032760
Location (UCSC)	Chr 10: 83.63 – 84.75 Mb	Chr 14: 39.18 – 40.29 Mb
PubMed search	[1]	[2]

Neuregulin 3 also known as NRG3 is a member of the neuregulin protein family which in humans is encoded by the NRG3 gene.^[1][2]

Function

NRG3 can bind to the extracellular domain of the ERBB4 receptor tyrosine kinase but not to the related family members ERBB2 or ERBB3. NRG3 binding stimulates tyrosine phosphorylation of ERBB4.^[2]

Clinical significance

Variants of the NRG3 gene have been linked to a susceptibility to schizophrenia.^[3][4]

References

1. ^ "Entrez Gene: NRG3 neuregulin 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10718. 
2. ^ ^{a b} Zhang D, Sliwkowski MX, Mark M, Frantz G, Akita R, Sun Y, Hillan K, Crowley C, Brush J, Godowski PJ (September 1997). "Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates ErbB4". Proc. Natl. Acad. Sci. U.S.A. 94 (18): 9562–7. doi:10.1073/pnas.94.18.9562. PMC 23218. PMID 9275162. http://www.pnas.org/cgi/pmidlookup?view=long&pmid=9275162. 
3. ^ Chen PL, Avramopoulos D, Lasseter VK, McGrath JA, Fallin MD, Liang KY, Nestadt G, Feng N, Steel G, Cutting AS, Wolyniec P, Pulver AE, Valle D (January 2009). "Fine mapping on chromosome 10q22-q23 implicates Neuregulin 3 in schizophrenia". Am. J. Hum. Genet. 84 (1): 21–34. doi:10.1016/j.ajhg.2008.12.005. PMC 2668048. PMID 19118813. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2668048. 
4. ^ Schizophrenia symptom linked to gene mutation - By Sam Ohmer 2/26/09

Further reading

• Benzel I, Bansal A, Browning BL, et al. (2007). "Interactions among genes in the ErbB-Neuregulin signalling network are associated with increased susceptibility to schizophrenia.". Behavioral and Brain Functions 3 (1): 31. doi:10.1186/1744-9081-3-31. PMC 1934910. PMID 17598910. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1934910. 
• Iijima M, Tomita M, Morozumi S, et al. (2009). "Single nucleotide polymorphism of TAG-1 influences IVIg responsiveness of Japanese patients with CIDP.". Neurology 73 (17): 1348–52. doi:10.1212/WNL.0b013e3181bd1139. PMID 19776380. 
• Shrestha S, Irvin MR, Taylor KD, et al. (2010). "A genome-wide association study of carotid atherosclerosis in HIV-infected men.". AIDS 24 (4): 583–92. doi:10.1097/QAD.0b013e3283353c9e. PMID 20009918. 
• Uhl GR, Liu QR, Drgon T, et al. (2008). "Molecular genetics of successful smoking cessation: convergent genome-wide association study results.". Arch. Gen. Psychiatry 65 (6): 683–93. doi:10.1001/archpsyc.65.6.683. PMC 2430596. PMID 18519826. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2430596. 
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1356129. 
• Gizatullin RZ, Muravenko OV, Al-Amin AN, et al. (2000). "Human NRG3 gene Map position 10q22-q23.". Chromosome Res. 8 (6): 560. doi:10.1023/A:1009232025144. PMID 11032326. 
• Panchal H, Wansbury O, Parry S, et al. (2007). "Neuregulin3 alters cell fate in the epidermis and mammary gland.". BMC Dev. Biol. 7: 105. doi:10.1186/1471-213X-7-105. PMC 2110892. PMID 17880691. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2110892. 
• Wang YC, Chen JY, Chen ML, et al. (2008). "Neuregulin 3 genetic variations and susceptibility to schizophrenia in a Chinese population.". Biol. Psychiatry 64 (12): 1093–6. doi:10.1016/j.biopsych.2008.07.012. PMID 18708184. 
• Révillion F, Lhotellier V, Hornez L, et al. (2008). "ErbB/HER ligands in human breast cancer, and relationships with their receptors, the bio-pathological features and prognosis.". Ann. Oncol. 19 (1): 73–80. doi:10.1093/annonc/mdm431. PMID 17962208. 
• Carteron C, Ferrer-Montiel A, Cabedo H (2006). "Characterization of a neural-specific splicing form of the human neuregulin 3 gene involved in oligodendrocyte survival.". J. Cell. Sci. 119 (Pt 5): 898–909. doi:10.1242/jcs.02799. PMID 16478787. 
• Gratacòs M, Costas J, de Cid R, et al. (2009). "Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6): 808–16. doi:10.1002/ajmg.b.30902. PMID 19086053. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Sonuga-Barke EJ, Lasky-Su J, Neale BM, et al. (2008). "Does parental expressed emotion moderate genetic effects in ADHD? An exploration using a genome wide association scan.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B (8): 1359–68. doi:10.1002/ajmg.b.30860. PMID 18846501. 
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054. 
• Volpi S, Heaton C, Mack K, et al. (2009). "Whole genome association study identifies polymorphisms associated with QT prolongation during iloperidone treatment of schizophrenia.". Mol. Psychiatry 14 (11): 1024–31. doi:10.1038/mp.2008.52. PMID 18521091.