- Muir–Torre syndrome
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Muir–Torre syndrome Classification and external resources
Micrograph of a sebaceous adenoma, as may be seen in Muir-Torre syndrome. H&E stain.OMIM 158320 DiseasesDB 31385 eMedicine derm/275 MeSH D055653 Muir–Torre syndrome (MTS) is an inherited cancer syndrome[1]:663 that is thought to be a subtype of HNPCC. Individuals are prone to develop cancers of the colon, breast and genitourinary tract, and skin lesions, such as keratoacanthomas and sebaceous tumours. The genes affected are MLH1 & MSH2, and involved in DNA mismatch repair.
Eponym
It is named for EG Muir and D Torre.[2][3]
References
- ^ James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.
- ^ Muir EG, Bell AJ, Barlow KA (March 1967). "Multiple primary carcinomata of the colon, duodenum, and larynx associated with kerato-acanthomata of the face". Br J Surg 54 (3): 191–5. doi:10.1002/bjs.1800540309. PMID 6020987.
- ^ Torre D (November 1968). "Multiple sebaceous tumors". Arch Dermatol 98 (5): 549–51. doi:10.1001/archderm.98.5.549. PMID 5684233.
External links
- Muir–Torre syndrome - Victoria Infirmary
Tumors: Skin neoplasm, skin appendages / Adnexal and skin appendage (C44.L40–L68/D23.L15–49, 173/216) Glands Apocrine: Cylindroma (Dermal cylindroma) · Syringocystadenoma papilliferum · Papillary hidradenoma · Hidrocystoma · Apocrine gland carcinoma · Apocrine nevus · Spiradenomaapocrine or eccrine: Syringoma · Acrospiroma (Malignant acrospiroma) · Hidradenoma/Hidradenocarcinoma
ungrouped: CeruminomaNevus sebaceous · Muir–Torre syndrome · Sebaceous carcinoma · Sebaceous adenoma · Sebaceoma · Sebaceous nevus syndrome · Sebaceous hyperplasia · MantleomaHair Pilomatrixoma/Malignant pilomatricoma · Trichoepithelioma (Multiple familial trichoepithelioma, Solitary trichoepithelioma, Desmoplastic trichoepithelioma, Generalized trichoepithelioma) · Trichodiscoma · Trichoblastoma · Fibrofolliculoma · Trichilemmoma · Trichilemmal carcinoma · Giant solitary trichoepithelioma · Trichofolliculoma · Trichoadenoma
Hamartoma: Basaloid follicular hamartoma · Folliculosebaceous cystic hamartoma · Folliculosebaceous-apocrine hamartoma
Isthmicoma · Fibrofolliculoma · Perifollicular fibroma · Birt–Hogg–Dubé syndromeNails Metabolic disease: DNA replication and DNA repair-deficiency disorder DNA replication Separation/initiation: RNASEH2A (Aicardi–Goutières syndrome 4)
Termination/telomerase: DKC1 (Dyskeratosis congenita)DNA repair Cockayne syndrome/DeSanctis–Cacchione syndrome · Thymine dimer (Xeroderma pigmentosum) · IBIDS syndromeOtherRecQ helicase (Bloom syndrome, Werner syndrome, Rothmund–Thomson syndrome/Rapadilino syndrome) · Fanconi anemia · Li-Fraumeni syndrome · Severe combined immunodeficiencysee also DNA replication, DNA repair
B structural (perx, skel, cili, mito, nucl, sclr) · DNA/RNA/protein synthesis (drep, trfc, tscr, tltn) · membrane (icha, slcr, atpa, abct, othr) · transduction (iter, csrc, itra), trfkCategories:- Disease stubs
- Epidermal nevi, neoplasms, cysts
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