Subiculum

Subiculum

Infobox Brain
Name = PAGENAME
Latin =
GraySubject =
GrayPage =


Caption = Subiculum labeled at center left.


Caption2 = Subiculum to CA1 transition Artist Don Cooper and Leah Leverich
IsPartOf = Temporal lobe
Components =
Artery = Posterior cerebral Anterior choroidal
Vein =
Acronym = S
BrainInfoType = hier
BrainInfoNumber = 170
MeshName = Subiculum
MeshNumber = A08.186.211.577.405
The subiculum (Latin for "support") is the most inferior component of the hippocampal formation. It lies between the entorhinal cortex and the CA1 subfield of the hippocampus proper.

It receives input from CA1 and entorhinal cortical layer III pyramidal neurons and is the main output of the hippocampus. The pyramidal neurons send projections to the nucleus accumbens, septal nuclei, prefrontal cortex, lateral hypothalamus, nucleus reuniens, mammillary nuclei, entorhinal cortex and amygdala.

The pyramidal neurons in the subiculum exhibit transitions between two modes of action potential output: bursting and single spiking. The transitions between these two modes is thought to be important for routing information out of the hippocampus.

It is the site responsible for ictal activity in some cases of human epilepsy. It has also been implicated in working memory and drug addiction.

References

* Amaral, D.G., Witter, M.P. (1995). Hippocampal Formation. In: The Rat Nervous System. Academic Press, 1995.
* O'Mara, S.M., Commins, S., Anderson, M. & Gigg, J.(2001). The Subiculum: A review of form physiology and function. Prog Neurobiol, 64, 129-154.
* O’Mara, S.M. (2006). The Mammalian Subiculum: Contrasting and Complementary In Vivo and In Vitro Approaches to Subicular Function. Special Issue of Behavioural Brain Research, 174 (2), 197-312.
* " [http://biology.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pbio.0030210 Switching Signals in the Brain] ," "PLoS Biology", 3(6):e210, 2005 June.
* [http://www3.utsouthwestern.edu/psychlab/cooper/ Donald C. Cooper] , Sungkwon Chung, Nelson Spruston, " [http://biology.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pbio.0030175 Output-Mode Transitions Are Controlled by Prolonged Inactivation of Sodium Channels in Pyramidal Neurons of Subiculum] ," "PLoS Biology", 3(6):e175, 2005 June.
* [http://www3.utsouthwestern.edu/psychlab/cooper/ Donald C. Cooper] , Shannon J. Moore, Nathan P. Staff, and Nelson Spruston, " [http://www.jneurosci.org/cgi/content/full/23/30/9937 Psychostimulant-induced plasticity of intrinsic excitability in the ventral subiculum] ," "Journal of Neuroscience", October 29, 2003, 23(30):9937-9946

External links

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* [http://www.anatomie.net/histowebatlas/m-426a.htm Photo]
* [http://edoc.hu-berlin.de/dissertationen/schubert-stephan-nicolas-2003-09-26/HTML/schubert_html_21d219b1.pngPhoto]
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  • subiculum — su·bic·u·lum …   English syllables

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