Matrine

Matrine
Matrine
Systematic (IUPAC) name
(7aS,13aR,13bR,13cS)-dodecahydro-1H,5H,10H-dipyrido[2,1-f:3′,2′,1′-ij][1,6]naphthyridin-10-one
Clinical data
Pregnancy cat.  ?
Legal status Unscheduled
Identifiers
CAS number 519-02-8 YesY
ATC code None
PubChem CID 91466
ChemSpider 553788 YesY
ChEMBL CHEMBL204860 N
Chemical data
Formula C15H24N2O 
Mol. mass 248.364 g/mol
SMILES eMolecules & PubChem
 N(what is this?)  (verify)

Matrine is an alkaloid found in plants from the Sophora family. It has a variety of pharmacological effects, including anti-cancer effects,[1] and action as a kappa opioid receptor agonist.[2][3]

Matrine possesses strong antitumor activities in vitro and in vivo. Inhibition of cell proliferation and induction of apoptosis are the likely mechanisms responsible for matrine's antitumor activities.[4]Matrine is a component of the traditional Chinese medical herb Sophora flavescens Ait, which is widely used to treat diseases such as viral hepatitis, cardiac arrhythmia and skin inflammations.

Matrine and the related compound oxymatrine have an antifeedant effect against Formosan subterranean termite.[5]

References

  1. ^ Zhang Y, Zhang H, Yu P, Liu Q, Liu K, Duan H, Luan G, Yagasaki K, Zhang G (April 2009). "Effects of matrine against the growth of human lung cancer and hepatoma cells as well as lung cancer cell migration". Cytotechnology 59 (3): 191–200. doi:10.1007/s10616-009-9211-2. PMC 2774570. PMID 19649719. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2774570. 
  2. ^ Xiao P, Kubo H, Ohsawa M, Higashiyama K, Nagase H, Yan YN, Li JS, Kamei J, Ohmiya S (April 1999). "kappa-Opioid receptor-mediated antinociceptive effects of stereoisomers and derivatives of (+)-matrine in mice". Planta Medica 65 (3): 230–3. doi:10.1055/s-1999-14080. PMID 10232067. 
  3. ^ Higashiyama K, Takeuchi Y, Yamauchi T, Imai S, Kamei J, Yajima Y, Narita M, Suzuki T (May 2005). "Implication of the descending dynorphinergic neuron projecting to the spinal cord in the (+)-matrine- and (+)-allomatrine-induced antinociceptive effects". Biological & Pharmaceutical Bulletin 28 (5): 845–8. doi:10.1248/bpb.28.845. PMID 15863891. 
  4. ^ Ma L., Wen S., Zhan Y., He Y., Liu X., Jiang J."Anticancer effects of the Chinese medicine matrine on murine hepatocellular carcinoma cells" Planta Medica 2008 74:3 (245-251)
  5. ^ Mao L., Henderson G. (2007). "Antifeedant activity and acute and residual toxicity of alkaloids from Sophora flavescens (Leguminosae) against formosan subterranean termites (Isoptera: Rhinotermitidae)". Journal of Economic Entomology 100 (3): 866–870. doi:10.1603/0022-0493(2007)100[866:AAAAAR]2.0.CO;2. PMID 17598549. 


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