Major histocompatibility complex, class II, DQ alpha 1
Major histocompatibility complex, class II, DQ alpha 1

Structure of HLA-DQA1 (cyan) complexed with HLA-DQB1 (green) and HCRT (magenta) based on PDB 1uvq.
Identifiers
Symbols HLA-DQA1; CD; CELIAC1; DQ-A1; FLJ27088; FLJ27328; GSE; HLA-DQA; MGC149527
External IDs OMIM146880 MGI95895 HomoloGene123820 GeneCards: HLA-DQA1 Gene
RNA expression pattern
PBB GE HLA-DQA1 212671 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3117 14960
Ensembl ENSG00000196735 ENSMUSG00000036594
UniProt P01907 Q3TB90
RefSeq (mRNA) XM_001134217 NM_010378.2
RefSeq (protein) XP_001134217 NP_034508.2
Location (UCSC) Chr 6:
32.6 – 32.61 Mb
Chr 17:
34.41 – 34.42 Mb
PubMed search [1] [2]

Major histocompatibility complex, class II, DQ alpha 1, also known as HLA-DQA1, is a human gene present on short arm of chromosome 6 (6p21.3) and also denotes the genetic locus which contains this gene.[1] The protein encoded by this gene is one of two proteins that are required to form the DQ heterodimer, a cell surface receptor essential to the function of the immune system.

Contents

Function

HLA-DQA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen-presenting cells (APC: B lymphocytes, dendritic cells, macrophages).[1]

Gene structure and polymorphisms

The alpha chain contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular protein domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation.[1][2]

Alleles

DQ1

There are four commonly encountered DQA1 alleles: DQA1*0101, *0102, *0103, *0104. These alleles are always found in haplotypes with HLA-DQB1*05 (DQ5) and HLA-DQB1*06 (DQ6). DQ1 is a serotype, rare among serotypes for human class II antigens, in that the antibodies to DQ1 react to the alpha chain of HLA DQ, these DQA1 allele gene products.

HLA-DQA1 alleles
DQA1 linked DQB1 allele
DQ1 *0101 *0501 *0301
*0102 *0502 *0504 *0602 *0604 *0605 *0609
*0103 *0501 *0502 *0601 *0602 *0603
*0104 *0501 *0503 *0602
*0105 rare
*0106 rare
See haplotype table in HLA-DQ. Unbolded are rare haplotypes
Link to haplotypes can be followed by DQB1 alleles

Other

The other DQA1 alleles have no defined serotype. There are 5 groups, DQA1*02, *03, *04, *05, *06. DQA1 within these groups are either invariant or produce the same α-chain subunit. DQA1*02 and DQA1*06 contain only one allele. DQA1*03 has three alleles which each produce nearly identical α3. For DQA1*05, the DQA1*0501 and DQA1*0505 produce identical α5. Other DQA1*05 exist that produce variant α5var, but these are rare.

HLA-DQA1 alleles
DQA1 linked DQB1 allele
*0201 *0202 *0303
*0301 *0202 *0302
*0302
*0303 *0301 *0602
*0401 *0303 *0401 *0402
*0501 *0201
*0505 *0301
*0601 *0301
See haplotype table in HLA-DQ. Unbolded are rare haplotypes
Link to haplotypes can be followed by DQB1 alleles

See also

References

  1. ^ a b c "Entrez Gene: HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3117. 
  2. ^ Lau M, Terasaki PI, Park MS (1994). "International Cell Exchange, 1994". Clin Transpl: 467–88. PMID 7547576. 

Further reading



Wikimedia Foundation. 2010.

Look at other dictionaries:

  • Major histocompatibility complex, class II, DP alpha 1 — Identifiers Symbol HLA DPA1 Alt. symbols HLA DP1A Entrez 3113 …   Wikipedia

  • Major histocompatibility complex — The major histocompatibility complex (MHC) is a large genomic region or gene family found in most vertebrates that encodes MHC molecules. MHC molecules play an important role in the immune system and autoimmunity. Proteins are continually… …   Wikipedia

  • MHC class II — Schematic representation of MHC class II MHC (major histocompatibility complex) Class II molecules are found only on a few specialized cell types, including macrophages, dendritic cells and B cells, all of which are professional antigen… …   Wikipedia

  • MHC class I — Schematic representation of MHC class I MHC class I molecules are one of two primary classes of major histocompatibility complex (MHC) molecules (the other one being MHC class II) and are found on every nucleated cell of the body (and thus not on …   Wikipedia

  • HLA-DQ — heteropolypeptide heteropolymer = MHC class II, DQ polymer type = heterodimer protein type = cell surface receptor function = Immune recognition and antigen presentation image source = DQ1 binding pocket with ligand SubunitCount = 2 subunit1 = α… …   Wikipedia

  • HLA-DQA1 — Major histocompatibility complex, class II, DQ alpha 1, also known as HLA DQA1, is a human gene and also denotes the genetic locus which contains this gene.cite web | title = Entrez Gene: HLA DQA1 major histocompatibility complex, class II, DQ… …   Wikipedia

  • List of A1 genes, proteins or receptors — This is a list of genes, proteins or receptors named A1 or Alpha 1 : Actin, alpha 1 Actinin, alpha 1 Adaptor related protein complex 2, alpha 1 Aldehyde dehydrogenase 3 family, member A1 Aldehyde dehydrogenase 4 family, member A1 Aldehyde… …   Wikipedia

  • District Attorney's Office v. Osborne — L arrêt District Attorney s Office v. Osborne de la Cour suprême des États Unis (18 juin 2009) refuse d accorder aux personnes condamnées un droit constitutionnel à un test ADN visant à les innocenter. L arrêt, écrit par le président de …   Wikipédia en Français

  • HLA-DQA2 — Major histocompatibility complex, class II, DQ alpha 2, also known as HLA DQA2, is a human gene.cite web | title = Entrez Gene: HLA DQA2 major histocompatibility complex, class II, DQ alpha 2| url =… …   Wikipedia

  • HLA-DQB1 — Major histocompatibility complex, class II, DQ beta 1, also known as HLA DQB1, is a human gene and also denotes the genetic locus which contains this gene.cite web | title = Entrez Gene: HLA DQB1 major histocompatibility complex, class II, DQ… …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”